Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE However, the role of exosomal PTEN in cell-cell communication during the progress of benzene-induced carcinogenesis remains unclear. 31812062

2020

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Because of importance of PTEN in tumorigenesis, a large number of sophisticated genetically engineered mouse models (GEMMs) has been designed to elucidate the underlying mechanisms by which the "PTEN pathway" promotes tumorigenesis, while simultaneously providing a well-tailored system for the identification of novel therapies and offering platforms for new drug discoveries. 31570383

2020

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE A mechanistic analysis showed that PTEN and p21 were involved in circGRAMD1B/miR-130a-3p axis-inhibited GC tumorigenesis. 31719211

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Ingenuity Pathways Analysis (IPA) identified many cancer related pathways including PTEN, p53, Nrf2 and inflammatory signaling in UVB-irradiation induced carcinogenesis. 30771437

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Knowledge of the intrinsic connections between PI3K/PTEN and KDR signaling, which represent two critical transitions in carcinogenesis, led the present study to investigate the effects of the potential synergy between ANLN and KDR on breast cancer outcome and identify relevant SNPs driving such a synergy at the genetic level. 31578580

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Our observations demonstrate an unexplored function of PTEN with the potential of global transcriptional regulation, adding a new dimension to somatic carcinogenesis and germline cancer predisposition. 31452836

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Finally, we investigated the mechanisms by which double PTEN/E2F-1 deficiency leads to enhanced tumorigenesis. 30206933

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Loss of PTEN is an important event in prostate carcinogenesis. 30854061

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The loss of phosphatase and tensin homolog (PTEN) activation by RCE impaired PI3K/Akt/Foxo and Jak/Stat activation pathways, which contributed to tumorigenesis.These multiple targets of <i>R. cymosa</i> against hematologic cancer cells suggested its potential application as an antileukemic dietary supplement. 31010164

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Data is limited regarding the variant allele frequency (VAF) of PIK3CA and PTEN expression during various stages of breast carcinogenesis. 30844755

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Importantly, we demonstrated that circPSMC3 could act as a sponge of miR-296-5p to regulate the expression of Phosphatase and Tensin Homolog (PTEN), and further suppress the tumorigenesis of gastric cancer cells. 30777076

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The PI3K/Akt/mTOR pathway is frequently altered in this poorly characterised carcinoma<sub>.</sub> IGF2 was identified here as a key factor in ASCC oncogenesis, as IGF2 was shown to play a crucial role in the PI3K pathway with frequent (~60%) and mutually exclusive genomic alterations in IGF2, IGF1R, PTEN and PIK3CA genes. 30714617

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Higher PTEN expression in DP-MSCs than in BM-MSCs is responsible for the lineage commitment and tumorigenesis differences in both cells. 31110221

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 PosttranslationalModification BEFREE Phosphorylation of PTEN plays an important role in carcinogenesis and progression of gastric cancer. 30930234

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE By using Hematoxylin and Eosin (H&E) staining, SMA and Masson's Trichrome staining, we investigated the effect of PTEN haploinsufficiency in combination with Runx2 overexpression on prostate tumorigenesis. 31281490

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Although the PTEN protein plays a pivotal role in carcinogenesis, cumulative evidence has implicated it as a key signaling molecule in several other diseases as well, such as diabetes, Alzheimer's disease, and autism spectrum disorders. 31454965

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Moreover, the GAS5/miR-21/PDCD4/PTEN and GAS5/miR-1284/AKT signaling pathway was found to be closely related to the tumorigenesis of PC. 30317620

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE We reported a potential regulatory loop that the NF-kB-induced miR-130b/301b overexpression decreased USP13 expression and subsequently resulted in the downregulation of PTEN protein and promoted tumorigenesis of bladder cancer. 31200745

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE This work highlights the instrumental role of PGK1 autophosphorylation in its activation and PTEN protein phosphatase activity in governing glycolysis and tumorigenesis. 31492635

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Significant modulation of both AKT, ERK, mTOR, p38, PTEN and Src genes and proteins were also observed in annonacin-targeted signaling pathway(s) against tumorigenesis. 31481122

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The development of carcinogenesis in the CLC and HCC-like areas in this case might differ, following a common PTEN mutation, although alteration of the kinase-RAS module is the most common molecular event in CLC. 31261448

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In this case, PCOS seemed to underlie the endometrial carcinogenesis and then concurrent loss of PTEN and PAX2 expression, confirmed by immunohistochemistry, can facilitate tumor progression. 29620584

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Mechanistically, these individual biomarkers affect multiple pathways critical to tumorigenesis and progression, including epithelial‑mesenchymal transition (EMT), phosphatase and tensin homolog (PTEN), Wnt, growth factor receptor, cell proliferation, immune checkpoints and others. 31638194

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Taken together, our results indicate that the Pten gene is a double-edged sword for carcinogenesis, and reinterpretation of the importance of the Pten gene in carcinogenesis is warranted. 31685992

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The tumors were sequenced for mutations in the TERT promoter and 22 additional cancer-related genes, interestingly; one patient was shown to carry a deleterious intronic variant in PTEN, a tumor suppressor gene coupled to thyroid tumorigenesis and Cowden syndrome. 31699114

2019