Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Gain-of-function (GOF) mutants of p53 upregulate genes implicated in cell proliferation and oncogenesis. 28423230

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Disruption of the p53 tumor suppressor pathway is a primary cause of tumorigenesis. 28460439

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE PI3KCA and mutant p53 are associated with tumorigenesis and the development of cancers. 29495002

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Genetic alterations such as activating KRAS and/or inactivating TP53 are thought to be the most common drivers to tumorigenesis. 28430579

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Recent findings from a prospective clinical study involving multiregion whole-exome sequencing suggest that driver mutations in cancer-relevant genes including EGFR and TP53 are often clonal and precede whole-genome duplication events in early lung carcinogenesis. 28668385

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The p53 tumor suppressor and its negative regulator, murine double minute 2 (MDM2), play critical roles in carcinogenesis. 26476535

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin Expression. 28760854

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These miRNAs, mRNAs, and lncRNAs may participate in p53 downstream signaling pathways and play important roles in the carcinogenesis of NPC. 26462838

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women. 26619844

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE TP53 mutations in p53-negative dysplastic urothelial cells from Belgian AAN patients: New evidence for aristolochic acid-induced molecular pathogenesis and carcinogenesis. 28477877

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. 26840028

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Combined Loss of EAF2 and p53 Induces Prostate Carcinogenesis in Male Mice. 29029019

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Although KRAS and TP53 mutations are common in both inflammatory bowel disease-associated colorectal cancer (IBD-CRC) and sporadic colorectal cancer (S-CRC), molecular events leading to carcinogenesis may be different. 28077799

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The CDKN1A gene product is a p53 downstream effector, which participates in cell differentiation, development process, repair, apoptosis, senescence, migration, and tumorigenesis. 26846214

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Extremely low mutation rate in classical tumor suppressor genes (such as p53 and pRb) and oncogenes (including Ras or myc) indicates that there would be MPM-specific carcinogenesis pathway. 25823924

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. 26271008

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE TP53 and RB1 inactivation events are also likely to contribute to tumorigenesis. 27067779

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These findings collectively reveal a novel role for the p53 target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53. 25813352

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Therefore, our findings reveal a novel mechanism of p53 inactivation that links deregulation of IRES-mediated p53 translation with tumorigenesis. 26391949

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE FBXW7 and TP53 are tumour suppressors intensively implicated in colorectal carcinogenesis. 25860929

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE LOH and TP53 mutations detected in LSCC and AC may be associated with tumorigenesis, whereas BRAF V600E mutation does not seem to significantly contribute to LSCC pathogenesis. 26084614

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Using p53-compromised cancer cells, we demonstrate that CARF induces growth arrest when wild type p53 is present and in p53-absence, it promotes carcinogenesis. 26278998

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE TP53 is one of the most frequently mutated genes in human cancer, and these alterations can occur during the early stages of oncogenesis or as later events as tumors progress to more aggressive forms. 26818199

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE In non-small cell lung cancer cells that contain a mutated KRAS gene, SIVA, a p53 target gene that is critical for apoptosis, is overexpressed in a p53-independent manner and promotes tumorigenesis through the stimulation of mTOR signaling. 26037915

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Over 50% of human cancers harbor cancer-causing mutant p53. p53 mutations not only abrogate its tumor-suppressor function, but also endow mutant p53 with a gain of function (GOF), creating a proto-oncogene that contributes to tumorigenesis, tumor progression, and chemo- or radiotherapy resistance. 26294215

2016