Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE It provides a proof-of-principle that co-targeting AR and PRDX1 may be more effective to control PCa growth. 31477836

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE The function of NE cells in PCa remains poorly understood, and one important characteristic of these cells is their lack of expression of AR and resistance to hormonal therapy. 30924452

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE The expression of AR in metastatic PC was up regulated, indicating the importance of AR signaling in the progression of this cancer. 31783154

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Androgen receptor (AR) plays a pivotal role in the development of male sex and contributes to prostate cancer growth. 31057123

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE The recent availability of selective AR inhibitors (e.g. bicalutamide, enzalutamide, apalutamide) approved for the treatment of prostate cancer has opened up the possibility to use them in BC patients whose tumors express AR. 31002873

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE 5α-Dihydrotestosterone (5α-DHT) possesses a great affinity for the androgen receptor (AR), and its binding to AR promotes the proliferation of prostate cancer (PC) cells in androgen-dependent PC. 31753699

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Inflammation is implicated in PCa initiation and progression and we have previously reported that the inflammatory cytokine, interleukin-1 (IL-1), represses AR messenger RNA (mRNA) levels and activity in AR-positive (AR<sup>+</sup> ) PCa cell lines concomitant with the upregulation of prosurvival biomolecules. 31730277

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE Mechanistically, we also showed that circZMIZ1 could increase the expression of androgen receptor (AR) and androgen receptor splice variant 7 (AR-V7), which may be partly contributed to the occurrence and development of prostate cancer. 31686520

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE The growth of PCa cells is stirred up by androgens and androgen receptor (AR). 31818479

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE Marked response to cabazitaxel in prostate cancer xenografts expressing androgen receptor variant 7 and reversion of acquired resistance by anti-androgens. 31799745

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE In conclusion, IL8 expression in the tumor microenvironment is associated with aggressive prostate cancer and with AR loss in metastatic disease. 31604846

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Prostate cancer development and progression is largely dependent on androgen receptor (AR) signaling. 31804970

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Mechanistically, KIF4A and AR form an auto-regulatory positive feedback loop in prostate cancer: KIF4A binds AR and AR-V7 and prevents CHIP-mediated AR and AR-V7 degradation; AR binds the promoter region of KIF4A and activates its transcription. 31796514

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Advanced prostate cancer is often treated with anti-androgens which target the androgen receptor (AR) on which the growth of the tumour depends. 31778359

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Together, these results provide the first detailed mechanism of how the AR can differentially alter PCa and BCa metastasis; thus, targeting the newly identified AR-miR-525-5p-SLPI axis may help suppress metastasis. 31843555

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation BEFREE Here we found that adding R-2HG or the mutant IDH1 R132H could promote PCa cell invasion in androgen receptor (AR)-negative PC3 cells or suppressing the AR in AR-positive C4-2 cells. 31846689

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Our findings illustrate a previously unknown regulatory mechanism in prostate cancer cell proliferation regulated by the MSI2-AR axis and provide novel evidence towards a strategy against prostate cancer. 31833612

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE In this review, we will summarize our current knowledge on the roles of JNK in the apoptosis, proliferation, migration and DNA repair as well as dissect the relationships between JNK and androgen receptor in prostate cancer. 31810118

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Although AR plays a key role, it is likely that other molecular pathways also contribute to PC, making it essential to identify and develop drugs against novel targets. 31769890

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE The heat shock protein 70 inhibitor VER155008 suppresses the expression of HSP27, HOP and HSP90β and the androgen receptor, induces apoptosis, and attenuates prostate cancer cell growth. 31222811

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Studies targeting the androgen receptor (AR) signaling pathway in aromatase inhibitor (AI)-resistant breast cancer are limited.Bicalutamide, one of the commonly used AR inhibitors in prostate cancer, in combination with AI, did not show synergistic activity in patients with estrogen receptor-positive and AI-resistant disease in this phase II, single-arm study.The clinical benefit rate and objective response rate at 6 months were 16.7% and 0%, respectively, and the study was terminated after the first stage. 31434793

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE In this review, we will provide a comprehensive view of the effects of taxanes on androgen receptor signaling in prostate cancer. 29900882

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Androgen and AR can stimulate both primary PC and castration-resistant PC. 31693255

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker BEFREE Deregulation of ARs has a vital role in the initiation and progression of PCa. 31599460

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression BEFREE Prostate cancer (PCa) progression is characterized by increased expression and transcriptional activity of the androgen receptor (AR). 31756402

2020