Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE Importantly, we find that higher HNF1B expression strongly predicts better prognosis of prostate cancer, alone or together with lower EZH2 expression. 31636385

2020

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation GWASCAT 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. 31562322

2019

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE Expression levels of HNF1B and ECI2 proteins were validated by immunohistochemistry and western blotting at different stages of prostate cancer development. 30655870

2019

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation GWASCAT Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA. 30410027

2018

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation GWASCAT Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016

2018

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 PosttranslationalModification BEFREE This tumor-suppressor activity is lost when HNF1B is silenced by promoter methylation in the progression to PC. 27732966

2016

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation GWASCAT Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21. 27262462

2016

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191

2016

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation GWASCAT Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. 26443449

2015

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation GWASCAT A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. 26034056

2015

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies. 26214421

2015

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation GWASCAT Two susceptibility loci identified for prostate cancer aggressiveness. 25939597

2015

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation GWASCAT Genome-wide association scan for variants associated with early-onset prostate cancer. 24740154

2014

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE Twelve genes (BAG1, DDR1, ERBB4, ESR1, HSPD1, IGFBP2, IGFBP5, NR4A1, PAWR, PIK3CG, RAP2A, and TPD52) were found to be associated with both HNF1b and prostate cancer risk. 23661456

2013

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa. 23464444

2012

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE A mediation analysis of 9,065 PCa cases and 9,526 controls failed to produce evidence that diabetes mediates the association of the HNF1B locus with PCa risk. 23193118

2012

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE As in studies from other populations, our findings indicate that HNF1B is also associated with prostate cancer risk in the Korean population. 21982019

2011

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes. 21499250

2011

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker BEFREE Some associations appear to be ancestry specific, such as HNF1B, which is associated with prostate cancer in European Americans and Latinos but not in African-Americans. 21459759

2011

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk. 21576123

2011

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE These associations remained significant after excluding HNF1B SNP rs4430796 (a known PCa risk factor) from the analysis. 20203524

2010

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation GWASCAT Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. 20676098

2010

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE The examined HNF1B variants have a highly specific effect on prostate cancer risk with no apparent association with any of the other studied cancer types. 20526366

2010

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 GeneticVariation BEFREE These findings indicate that the HNF1B variants are directly associated with both diabetes and prostate cancer, that diabetes does not mediate these gene variant-prostate cancer relationships, and the relationship between these diseases is not mediated through these gene variants. 19998368

2010

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression BEFREE Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer. 20569440

2010