Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 AlteredExpression BEFREE Altogether, our results demonstrate that miR-337-3p is a tumor suppressor in EOC that inhibits the expression of PIK3CA and PIK3CB. 31629932

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 AlteredExpression BEFREE The aim of this study is to investigate the role of PI3K/Akt/mTOR signaling pathway and its association with epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) marker expression in EOC chemoresistance. 31234823

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE We aimed to assess the safety and identify the recommended phase 2 dose of the PARP inhibitor olaparib in combination with the PI3K inhibitor alpelisib in patients with epithelial ovarian cancer and in patients with breast cancer. 30880072

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE HYOU1 promotes cell growth and metastasis via activating PI3K/AKT signaling in epithelial ovarian cancer and predicts poor prognosis. 31173282

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE Through MAPK and PI3K/AKT signaling pathways, TMEFF1 promotes the malignant behavior in EOC. 30697076

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE These results suggested that TPT1-AS1 induced EOC tumor growth and metastasis through TPT1 and downstream PI3K/AKT signaling and that TPT1-AS1 may be a promising therapeutic target for EOC. 30941821

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE Therefore, the miR-936/FGF2/PI3K/Akt pathway is a promising therapeutic target for the treatment of EOC patients. 31371979

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE We also revealed that lncRNA AB0736141 knockdown inhibited the PTEN/PI3K/AKT signaling pathway in EOC. 30909184

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE We believe that GnRH agonists may be potential antitumor agents, and key factors in the PI3K/AKT-FOXO1 pathway may also be novel therapeutic targets for the treatment of EOC. 29286125

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 AlteredExpression BEFREE During tumor progression, epithelial ovarian cancer (EOC) maintains E-cadherin expression and can positively affect EOC cell growth by contributing to PI3K/AKT activation. 29996940

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE Thus, we investigated the effect of TLR-stimulated PI3K activation on the epithelial-to-mesenchymal transition (EMT) of primary (Caov-3) and metastatic (SK‑OV‑3) epithelial ovarian cancer cell lines in this study. 28350104

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE Collectively, this study emphasized the importance of leptin in OC progression and illustrated a novel mechanism that the PI3K/Akt/mTOR pathway was involved in leptin-induced EMT. 28002999

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE LncRNA MALAT1 promotes proliferation and metastasis in epithelial ovarian cancer via the PI3K-AKT pathway. 28770968

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 GeneticVariation BEFREE A patient with V600E BRAF-mutant melanoma and another with platinum-refractory epithelial ovarian cancer exhibiting PTEN loss and PIK3CA amplification demonstrated partial response by RECIST and GCIG-CA125 criteria, respectively. 25370471

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE In conclusion, the results of the present study demonstrated that PI3K/AKT and Rab25 significantly contributed to cisplatin resistance in human epithelial ovarian cancer; in addition, silencing Rab25 or inhibiting the PI3K/AKT pathway markedly increased the sensitivity of these cells to cisplatin. 25405658

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE We searched all potentially relevant studies published between January 1, 1990, and March 1, 2013, that assessed the association between PTEN, PI3K, and Akt status and survival in EOC. 24718516

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE Identification of the IGF1/PI3K/NF κB/ERK gene signalling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer. 24237932

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE Therefore, Ubc9 gene plays an important role in cell proliferation in EOC through PI3K/Akt signaling pathway. 23708104

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 AlteredExpression BEFREE WAVE1 might promote the proliferative and invasive malignant behaviors through the activation of the PI3K/AKT and p38MAPK signaling pathways in EOC. 23680521

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 AlteredExpression BEFREE Epithelial ovarian cancer (EOC) cells often show increased activity of the PI3K/Akt pathway. 20661217

2010

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE PIK3CA amplification was seen in 54 of 152 (35.5%) EOC cases analyzed; PIK3CA gene mutations in 6/153 EOC (3.9%); KRAS mutations in 3/154 EOC (1.9%), BRAF mutations in 3/156 EOC (1.9%), p53 mutation in 50/154 EOC (32.5%), and loss of PTEN protein expression in 33/144 EOC (22.9%). p110 alpha overexpression was associated with increased phosphorylation of AKT-Ser 473 and with the proliferation marker Ki-67. 19638206

2009

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE The finding that E-cadh-mediated AJ formation contributes to PI3K/AKT activation in EOC cells by a mechanism that appears to be restricted to these cells provides the underpinning for therapeutic strategies that exploit PI3K inhibition to halt EOCs. 19151754

2009

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 Biomarker BEFREE The aim of this study was to evaluate associations between common germline genetic variants in the oncogenes BRAF, ERBB2, KRAS, NMI, and PIK3CA, and survival after a diagnosis of epithelial ovarian cancer. 18794094

2008

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 AlteredExpression BEFREE Here, we investigated the genomic alterations and gene expression of most known PI3K family members in human epithelial ovarian cancer. 17875760

2007

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer
0.200 CausalMutation CLINVAR