Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE The beneficial role of SIRT1 activator on chemo- and radiosensitization of breast cancer cells in response to IL-6. 31781916

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE The ratios of granulocyte macrophage colony-stimulating factor and interleukin 1β cytokines, produced in tumor, to the expression of CSF2RA and IL1R2 depend on levels of interleukin 6, interleukin 8, tumor necrosis factor α, interferon γ, granulocyte colony-stimulating factor, and vascular endothelial growth factor A and are important factors affecting the progression and metastasis of the breast cancer. 31635541

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Glucans were also able to lower IL-1β and IL-6 secretion by LPS-activated THP-1/M cells and showed cytotoxic effect on a breast cancer cell line that was not observed on normal breast cells. 31826486

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE These findings indicate that IL-6 downregulates the tumor suppressor HIC1 and promotes BrCA development in the tumor microenvironment through paracrine or autocrine signaling. 31795965

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Tubulosine exhibited anticancer activity in IL-6-stimulated human breast cancer cells. 31598337

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE C/EBPδ links IL-6 and HIF-1 signaling to promote breast cancer stem cell-associated phenotypes. 30262865

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Specifically, IL-6 promoted the proliferation of normal cells and CCL2 induced the M2-like polarization of macrophages, which might create an immunosuppressive microenvironment during the initiation and/or development of breast cancer. 30671946

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Breast cancer cell lines T47D and MCF7 were exposed to IL-6, the expression of PIM1 was examined by quantitative real-time PCR (qRT-PCR) and western blot. 30989585

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 GeneticVariation BEFREE We're confused about some data in a recent article entitled "Polymorphic variation in IL-1, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women", which was published online in Cytokine. 30075885

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE We investigated whether vitamin D receptor (<i>VDR</i>) polymorphisms were associated with cancer biomarkers, i.e., E-cadherin, matrix metallopeptidase 9 (MMP9), interferon β (IFNβ), soluble intercellular adhesion molecule-1 (s-ICAM-1), soluble vascular cell adhesion molecule-1 (s-VCAM-1), tumor necrosis factorα (TNFα), interleukin 6 (IL6), plasminogen activator inhibitor-1(PAI-1), and human high sensitivity C-reactive protein (hs-CRP), among breast cancer survivors who received vitamin D3 supplementation. 31167402

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE We performed the Wechsler Memory Scale-Revised (WMS-R) test and measured plasma IL-6 levels for 47 breast cancer surgical patients within 1 year after the initial therapy (study 1) and more than 2 years after study 1 (study 2). 30168090

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Results support the use of MBSR(BC) to reduce salivary cortisol and IL-6 levels in the short term in BCS. 30079756

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE However, IL-6 was not found to be associated with breast cancer risk. 30962499

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE This effect was potentiated in the presence of human IL-6 at concentrations reported to be expressed in clinical breast cancer. 31515600

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE These results highlight that the survival of breast cancer patients with high co-expression of VEGF and IL-6 family cytokines is dependent on breast cancer subtype. 30439625

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE The aim of the current study was to assess the effect of coenzyme Q10 supplementation on serum levels of interleukin 6, 8, and vascular endothelial growth factor (VEGF) in patients with breast cancer undergoing tamoxifen therapy by a double-blind, placebo-controlled, randomized clinical trial. 31824163

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Serum IL-6 level (hazard ratio, 13.230; 95% confidence interval, 1.285-136.214; P=0.030) and triple-negative subtype (hazard ratio, 11.739; 95% confidence interval, 1.415-97.362; P=0.023) were independent prognostic factors for OS, and CRP expression level was an independent prognostic factor for RFS in patients with breast cancer (hazard ratio, 18.571; 95% confidence interval, 2.240-153.949; P=0.007). 31186728

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Inhibition of 3β-Hydroxysteroid Dehydrogenase Type 1 Suppresses Interleukin-6 in Breast Cancer. 31004874

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Interleukin-6 and interleukin-8 serum levels in prognosis of hormone-dependent breast cancer. 29482885

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE These data indicate that antagonizing IL6 together with Hh pathway inhibitors may be a novel therapeutic strategy for breast cancer. 30578886

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Cytokines such as interleukin-6 (IL-6), oncostatin M (OSM), and interleukin-1 beta (IL-1β) promote the development of both acute and chronic inflammation while promoting <i>in vitro</i> metrics of breast cancer metastasis. 31007849

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2. 29540614

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 GeneticVariation BEFREE Single nucleotide polymorphisms in ATM, TNF-α and IL6 genes and risk of radiotoxicity in breast cancer patients. 30442350

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE In the present study, the effects of IL-6 receptor (IL-6R) on breast cancer aggressiveness and bone metastases were investigated. 29557068

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Therefore, it seems that targeting IL-6 and/or its receptor in combination with other potent anticancer therapies may be a potent therapeutic approach for breast cancer therapy. 30372844

2018