Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 Biomarker BEFREE CNVs in DCC/18q and ERBB2/17q are significantly associated with DFS in Stage II-III MSS colon cancer. 28006840

2017

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 Biomarker BEFREE Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. 18054557

2007

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 Biomarker BEFREE According to Fearon and Vogelstein model, further somatic mutations in the K-ras oncogene, DCC gene and p53 tumor suppressor gene are prerequisite for development of colon carcinoma. 11263856

2000

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 GeneticVariation BEFREE The deleted in colorectal cancer (DCC) gene was initially described as a colon cancer-associated tumor suppressor gene and subsequently proposed to be involved in goblet cell differentiation, but its precise role in normal intestine physiology and in cancer remains to be established. 10328236

1999

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 AlteredExpression BEFREE Quantitation of DCC protein expression in tissue specimens by densitometry demonstrated that both normal and malignant specimens exhibit a wide range of DCC protein levels and there was no significant correlation between diminished DCC protein expression and colon cancer progression. 8761300

1996

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 Biomarker BEFREE In order to clarify the association between bcl-2 protein (Bcl-2) expression and genetic alteration, we investigated p53 and DCC (deleted in the colon carcinoma gene locus) gene abnormalities in Bcl-2-positive and -negative gastric carcinomas using a polymerase chain reaction/loss of heterozygosity (LOH) assay. 8690754

1996

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 GeneticVariation BEFREE Human colon cancer development is associated with the accumulation of mutations and deletions in the suppressor genes DCC, APC and p53 and mutations in the dominant oncogene K-ras, with loss of wild type alleles. 7970729

1994

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 AlteredExpression BEFREE Lack of correlation between the gap junctional communication capacity of human colon cancer cell lines and expression of the DCC gene, a homologue of a cell adhesion molecule (N-CAM). 8396566

1993

Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 GeneticVariation BEFREE Because both ovarian and colon cancer are features of Lynch syndrome II, which has been provisionally mapped to chromosome 18, we hypothesized that loss of heterozygosity at the DCC locus may also occur in ovarian neoplasia. 1594239

1992