Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4512
Gene Symbol: COX1
COX1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.070 Biomarker BEFREE Overall these results suggest that DIM is a potent and dual COX1/2 and ERK1/2 inhibitor that might be used for chemotherapy against colon cancer. 30716361

2019

Entrez Id: 4512
Gene Symbol: COX1
COX1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.070 Biomarker BEFREE In this study, using colon cancer as an example, we provide both in vitro (cell culture) and in vivo (chemically induced mouse model of colon cancer) evidence that this profound antineoplastic action may be associated with aspirin's ability to irreversibly inhibit COX-1-mediated platelet activation, thereby blocking platelet-cancer cell interactions, which promote cancer cell number and invasive potential. 27998883

2017

Entrez Id: 4512
Gene Symbol: COX1
COX1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.070 AlteredExpression BEFREE Aspirin prevents cardiovascular disease and colon cancer; however aspirin's inhibition of platelet COX-1 only partially explains its diverse effects. 27566955

2016

Entrez Id: 4512
Gene Symbol: COX1
COX1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.070 AlteredExpression BEFREE COX-1 expression increased proportionally to COX-2 expression in colon cancer tissue from untreated patients. 20043083

2010

Entrez Id: 4512
Gene Symbol: COX1
COX1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.070 Biomarker BEFREE The results suggest, however, that aberrant cytochrome c oxidase subunit I expression may be a better biomarker than loss of apoptosis competence for increased colon cancer risk. 16172211

2005

Entrez Id: 4512
Gene Symbol: COX1
COX1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.070 AlteredExpression BEFREE Overexpression of COX-2 and decreased expression of COX-1 have been suggested to be characteristics of colon cancer. 16091009

2005

Entrez Id: 4512
Gene Symbol: COX1
COX1
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.070 Biomarker BEFREE Nonsteroidal antiinflammatory drugs inhibiting cyclooxygenase (COX) enzyme activity in both its constitutive (COX-1) and inducible (COX-2) isoforms were shown also to inhibit the development of colon carcinoma in animal models. 10931458

2000