Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE We propose that inhibition of the WNT pathway, particularly β-catenin, may bypass resistance to MEK inhibition in human PIK3CA mt colon cancer. 30944457

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE A molecular sub-cluster of colon cancer cells with low VDR expression is sensitive to chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors treatment. 31596728

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Omentin-1 could inhibit the proliferation and promote apoptosis of colon cancer stem cells in vitro via the PI3K/Akt pathway. 30941956

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 GeneticVariation BEFREE A preventive potential of high calcium intake against colorectal cancer has been indicated for distal colon cancer, which is inversely associated with high-level CpG island methylator phenotype (CIMP), high-level microsatellite instability (MSI), and BRAF and PIK3CA mutations. 30963391

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Applied to a novel perturbation dataset on PI3K and MAPK pathways in isogenic models of a colon cancer cell line, it generates plausible network hypotheses that explain distinct sensitivities toward various targeted inhibitors due to different PI3K mutants. 31510692

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE We eventually investigated activation of PI3K/Akt signaling by CXCL12 regulate PTEN and involved in the metastatic process of colon cancer. 31500630

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE We showed that PL displayed potent antineoplastic activity against colon cancer cell growth by targeting Ras proteins and PI3K/Akt signaling cascade. 30551398

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway. 30195873

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE COMP promoted colon cancer cell proliferation partially through the activation of PI3K/ Akt/ mTOR/ p70S6K pathway. 29560517

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE In this view, this study aims to explore the function of FBXL5 in the progression of colon cancer and determine if PI3K/AKT signaling pathway involves in this process. 30257389

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Meanwhile, our results also demonstrated that silencing of Linc00659 expression leads to cell growth inhibition and induced apoptosis, possibly by suppressing PI3K-AKT signaling in colon cancer. 29523145

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE CXCL12 gene silencing down-regulates metastatic potential via blockage of MAPK/PI3K/AP-1 signaling pathway in colon cancer. 29305742

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE The series exhibited a potential PI3Kα inhibitory activity in HCT-116 cell line. 28901259

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Pharmacological Inhibition of Casein Kinase 2 Enhances the Effectiveness of PI3K Inhibition in Colon Cancer Cells. 30396937

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 GeneticVariation BEFREE Fisher's exact test showed that only two detected mutations at BRAF (V600E) and PIK3CA (E542K) were significantly positively correlated with right-sided colon cancer. 29556349

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 GeneticVariation BEFREE Patients with right colon cancer showed more mutated BRAF (39.1% vs. 5.4%), mutated PIK3CA (13% vs. 1.4%), poorly differentiated tumor (17.4% vs. 3.4%), and peritoneal involvement (26.1% vs. 8.8%) than those with left colon and rectal cancer. 29169325

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Moreover, with our resveratrol-mesoporous silica nanoparticles formulation, we have observed that the permeability of resveratrol encapsulated in MCM-48 nanoparticles (90 nm) can be enhanced compared to a resveratrol suspension when tested through the human colon carcinoma cell monolayer (Caco-2). 29094948

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE The present study demonstrated that upregulation of miR-542-3p inhibited the growth and invasion of colon cancer cells through PI3K/AKT/survivin signaling, highlighting a novel therapeutic approach for the treatment of colon cancer. 29130099

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 AlteredExpression BEFREE We eventually investigated activation of PI3K/Akt/mTOR signaling by CXCL12 involved in the metastatic process of colon cancer. 28811711

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE The PI3K/Akt/mTOR pathway plays a crucial role in the pathogenesis of colon cancer. 28979133

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Our data also suggested that the PI3K/AKT signaling pathway links PRDX2 with 5-FU-induced apoptosis in colon cancer. 28432271

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. 28782499

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE However, selective targeting of oncogenic MAPK-PI3K hub in colon cancer has remained highly challenging, hence it has mostly been unexplored. 30023564

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 Biomarker BEFREE Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis. 28881576

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.100 GeneticVariation BEFREE <b>Methods:</b> Patient-derived tumor cells were collected from the ascites of a refractory colon cancer patient with wild-type RAS and PIK3CA mutation. 28928860

2017