Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 AlteredExpression BEFREE Thus, the present study suggests that activation of SRC is responsible for doxorubicin resistance in colon cancer. 29581735

2018

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 AlteredExpression BEFREE Dual inhibition of MET and SRC kinase activity as a combined targeting strategy for colon cancer. 28810597

2017

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 AlteredExpression BEFREE Cytoplasmic Localization of RUNX3 via Histone Deacetylase-Mediated SRC Expression in Oxidative-Stressed Colon Cancer Cells. 27990641

2017

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE These results implicate alternative targeting of MET or SRC as rational strategies for reversing cetuximab resistance in colon cancer. 24714091

2014

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE Importantly, hyperactivation of SRC/EGFR signaling triggered by loss of PTPRO leads to high resistance of colon cancer to EGFR inhibitors. 25301722

2014

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE However, although Src protein is increased in colon cancer as early as the adenomatous polyp stage, a role for Src in carcinogenesis has not been established. 18351644

2008

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 Biomarker BEFREE Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitro. 12820418

2003

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE However, two subsequent studies have failed to confirm the occurrence of SRC 531 mutation in colorectal cancers from North-European and Asiatic patients, raising the hypothesis that the genetic activation of src in colon cancer might be restricted to patients belonging to specific ethnic groups. 11161376

2001

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE Thus, mutation at Gln-531 of src gene does not seem to be involved in the development of colon cancer in Chinese ethnicity. 10704743

2000

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 GeneticVariation BEFREE These results provide, for the first time, genetic evidence that activating SRC mutations may have a role in the malignant progression of human colon cancer. 9988270

1999

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.400 CausalMutation CGI