Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 GeneticVariation BEFREE We analyzed germline CHEK2 variants in 1,928 high-risk Czech breast/ovarian cancer (BC/OC) patients and 3,360 population-matched controls (PMCs). 31050813

2019

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 Biomarker BEFREE Our study indicated that Chk2 and p27 were vital anticancer targets of TF3 and provided more evidence that TF3 might be a potent agent to be applied as adjuvant treatment for ovarian cancer. 30769778

2019

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 Biomarker BEFREE The recent approval of three different PARP inhibitors for the treatment of ovarian cancer provides the impetus for further developing targeted inhibitors of many of the kinases involved in the DDR, including inhibitors of ATR, ATM, CHEK1, CHEK2, DNAPK and WEE1. 28984489

2017

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 GeneticVariation BEFREE In this study, we have genotyped 68 MBC patients for the known breast or ovarian cancer associated mutations in the Finnish population in CHEK2, PALB2, RAD51C, RAD51D, and FANCM genes. 28874143

2017

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 Biomarker BEFREE Chk2-depleted ovarian cancer cell lines have diminished platinum sensitivity, suggesting that Chk2 should not be considered a therapeutic target along with platinum-based treatment in HGSOC patients. 24657486

2014

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 GeneticVariation BEFREE Thirty-one percent of ovarian carcinomas had a deleterious germline (24%) and/or somatic (9%) mutation in one or more of the 13 homologous recombination genes: BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK1, CHEK2, FAM175A, MRE11A, NBN, PALB2, RAD51C, and RAD51D. 24240112

2014

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 GeneticVariation BEFREE Our findings suggest that CHEK2 mutations may not contribute significantly to breast/ovarian cancer risk in Pakistani women. 23806170

2013

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 GeneticVariation BEFREE We discussed the potential application of CHEK2 variants in the evaluation of breast and ovarian cancer predisposition. 21120647

2011

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 Biomarker BEFREE Loss of Chk2 protein in ovarian cancer was not associated with allelic status, suggesting that inactivation does not occur as a consequence of haploinsufficiency. 17145815

2006

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 GeneticVariation BEFREE Positive associations were seen with the CHEK2 I157T missense variant and ovarian cystadenomas (OR = 1.7; P = 0.005), with borderline ovarian cancers (OR = 2.6; P = 0.002) and with low-grade invasive cancers (OR = 2.1; P = 0.04). 16828850

2006

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 GeneticVariation BEFREE Between 2002-2005, probands from 300 US families with 4 or more cases of breast or ovarian cancer but with negative (wild-type) commercial genetic test results for BRCA1 and BRCA2 were screened by multiple DNA-based and RNA-based methods to detect genomic rearrangements in BRCA1 and BRCA2 and germline mutations of all classes in CHEK2, TP53, and PTEN. 16551709

2006

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 GeneticVariation BEFREE These results suggest that variations in CHEK2 do not make a significant contribution to the pathogenesis of OvCa in the U.S. population. 15385111

2004

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 GeneticVariation BEFREE This is the first study from South India, on BRCA1, BRCA2 & CHEK2 (1100 del C) mutations in patients with a family history of breast and/or ovarian cancer and early onset breast/ovarian cancer, using the sensitive DHPLC approach. 14507240

2003

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.200 GeneticVariation CLINVAR