Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.190 AlteredExpression BEFREE Ovarian cancer tissues showed lower miR-203a-3p levels and higher ATM levels than adjacent normal tissues, both of which were associated with the FIGO stage, grade and prognosis of ovarian cancer. 31277702

2019

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.190 Biomarker BEFREE <i>Chlamydia trachomatis</i> infections are epidemiologically associated with cervical and ovarian cancers.Previously, we showed that <i>C. trachomatis</i> induces DNA double-strand breaks (DSBs) but suppresses Ataxia-telangiectasia mutated (ATM) activation and cell cycle checkpoints. 30401777

2018

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.190 Biomarker BEFREE The recent approval of three different PARP inhibitors for the treatment of ovarian cancer provides the impetus for further developing targeted inhibitors of many of the kinases involved in the DDR, including inhibitors of ATR, ATM, CHEK1, CHEK2, DNAPK and WEE1. 28984489

2017

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.190 Biomarker BEFREE Relative risks of ovarian cancer greater than two-fold were also observed for ATM, but could reliably be ruled out for RAD50 and CHEK2. 28888541

2017

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.190 GeneticVariation BEFREE Challenges in Interpreting Germline Mutations in BARD1 and ATM in Breast and Ovarian Cancer Patients. 28139868

2017

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.190 GeneticVariation BEFREE Thirty-one percent of ovarian carcinomas had a deleterious germline (24%) and/or somatic (9%) mutation in one or more of the 13 homologous recombination genes: BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK1, CHEK2, FAM175A, MRE11A, NBN, PALB2, RAD51C, and RAD51D. 24240112

2014

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.190 GeneticVariation BEFREE Contributions of ATM mutations to familial breast and ovarian cancer. 12810666

2003

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.190 GeneticVariation BEFREE One of the many substrates of ATM is BRCA1 (breast cancer 1, early onset gene), which has been associated with susceptibility to breast and ovarian cancer, and has been implicated in DNA repair processes. 14630541

2003

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.190 Biomarker BEFREE To investigate the role of ATM in ovarian cancer, we used a PCR-based single-strand conformation polymorphism assay for mutation detection of the entire coding sequence of the ATM gene (65 exons) in 22 ovarian tumors. 9949303

1999

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.190 GeneticVariation CLINVAR