Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE A dominant RAD51C pathogenic splicing variant predisposes to breast and ovarian cancer in the Newfoundland population due to founder effect. 31782267

2020

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Paired analysis of tumour-derived versus blood-derived DNA to determine the prevalence of deleterious somatic variants in OC predisposition genes (<i>ATM</i>, <i>BRCA1/2, BRIP1</i>, <i>MSH2/6</i>, <i>PALB2</i>, <i>RAD51C/D</i> and <i>TP53</i>) and the <i>PIK3CA</i> and <i>PTEN</i> genes in individuals with OC (AGO-TR1 study, NCT02222883). 30979843

2019

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE The analysis also showed a substantial difference in the profile of genes contributing to either BC or OC risk, including genes specifically associated with a high risk of OC but not BC (e.g., RAD51C, and RAD51D). 30733081

2019

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Loss-of-function variants in RAD51C are associated with familial ovarian cancer, but its role in hereditary breast cancer remains unclear. 30949688

2019

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Population-based BRCA1/BRCA2/RAD51C/RAD51D/BRIP1/PALB2 testing can prevent 1.86%/1.91% of BC and 3.2%/4.88% of OC in UK/US women: 657/655 OC cases and 2420/2386 BC cases prevented per million. 29361001

2018

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 PosttranslationalModification BEFREE Promoter methylation of BRCA1 and RAD51C was evaluated using methylation-sensitive PCR in 332 primary ovarian carcinomas. 29233532

2018

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE The rare finding of a clearly truncating RAD51C mutation in an early-onset BC patient with a BC-only family history supports the notion that compromised RAD51C function may result in both BC and OC. 27622768

2017

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Despite a high prevalence of deleterious missense variants, most studies of RAD51C ovarian cancer susceptibility gene only provide in silico pathogenicity predictions of missense changes. 28829762

2017

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE The results of pedigree analysis showed that the proband with a large deletion on RAD51C had a family history of both breast and ovarian cancer, and the families of probands with novel BRIP1 missense variants included a male patient with breast cancer or many patients with breast cancer within the second-degree relatives. 28796317

2017

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE RAD51C has been identified as a potential tumor suppressor and a breast and ovarian cancer susceptibility gene. 27753535

2016

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Overall, pathogenic RAD51C mutations were identified in 0.5 % of Danish families with increased risk of hereditary breast and/or ovarian cancer. 26740214

2016

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE We evaluated 11 genes associated with ovarian carcinoma (BARD1, BRCA1, BRCA2, BRIP1, MLH1, MSH2, MSH6, PALB2, PMS2, RAD51D, and RAD51C) and additional candidate genes in DNA repair (ATM, BAP1, CHEK2, MRE11A, NBN, PTEN, TP53). 26718727

2016

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE The RAD51 paralog RAD51C has been identified as a breast and ovarian cancer susceptibility gene. 25292178

2015

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE In 2010 an important finding was published showing that heterozygous mutations in RAD51C were highly penetrant and were able to confer an increased risk for breast and ovarian cancers. 26406419

2015

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE RAD51C is primarily an ovarian cancer susceptibility gene. 25470109

2015

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Although the cumulative frequency of RAD51C and RAD51D truncating mutations in our patients was lower than that of the BRCA1 and BRCA2 genes, it may explain OC susceptibility in approximately 3% of high-risk OC patients. 26057125

2015

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 26261251

2015

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Our results support that RAD51C is a rare breast and ovarian cancer susceptibility gene and may contribute to a small fraction of families including breast and ovarian cancer cases and families with only breast cancer. 25086635

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Deleterious and missense mutations of RAD51C have recently been suggested to modulate the individual susceptibility to hereditary breast and ovarian cancer and unselected ovarian cancer, but not unselected breast cancer (BrC). 25343521

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Biallelic RAD51C mutations cause Fanconi anemia, and monoallelic mutations predispose women to breast and ovarian cancer. 24800917

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Thirty-one percent of ovarian carcinomas had a deleterious germline (24%) and/or somatic (9%) mutation in one or more of the 13 homologous recombination genes: BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK1, CHEK2, FAM175A, MRE11A, NBN, PALB2, RAD51C, and RAD51D. 24240112

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Germline RAD51C mutations in ovarian cancer susceptibility. 22725699

2013

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE There is ongoing debate whether pathogenic RAD51C alterations increase the relative risk for BC in addition to that for OC, which was estimated to be 5.88 (95% confidence interval = 2.91 to 11.88; P = 7.65 × 10(-7)). 24359560

2013

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Our data confirm a consistent but low frequency (2/335 families) of inactivating RAD51C mutations among families with a history of both breast and ovarian cancer and an absence of mutations among breast cancer only families (0/1,053 families). 21990120

2012

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Germline mutations in RAD51C contribute marginally to breast and ovarian cancer susceptibility in ethnically diverse, Jewish high risk families. 23117857

2012