Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 AlteredExpression BEFREE MicroRNA-374b accelerates the development of lung cancer through downregulating PTEN expression via activating PI3K/Akt pathway. 30779080

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE To date, PI3K inhibitors have not been approved for lung cancer. 31337981

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Furthermore, cotreatment with sesamin and CAY10404 markedly reduced the levels of phosphorylated protein kinase B (pAkt) and phosoinositide 3 kinase (PI3K) in three lung cancer cell lines. 30365050

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 AlteredExpression BEFREE Consistently, DOK7V1 overexpression in lung cancer cells suppressed the phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathways, but activated the focal adhesion kinase (FAK)/paxillin signaling pathway. 30431081

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Mutations in EGFR, KRAS, BRAF, and PIK3CA genes are widely analyzed in solid tumors such as lung cancer, colorectal cancer, breast cancer, and melanoma. 29304903

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE The phosphoinositide 3-kinase (PI3K)/AKT/mechanistic target of rapamycin (mTOR) signaling has been shown to contribute to tumorigenesis, tumor progression, and resistance to therapy in most human cancer types, including lung cancer. 31262325

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Dual molecular targeted therapy for mTOR and PI3K may be a promising therapeutic strategy in the specific population of patients with lung cancer with LKB1 loss. 30825612

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Co-mutations in <i>TP53</i> and the <i>PI3K/AKT/mTOR</i> pathway confer additional resistance to anti-HER2 treatments in lung cancer. 31748336

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways. 30787353

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Additionally, Aclidinium Bromide suppressed the PI3K/AKT signaling pathway in lung cancer A549 cells. 31128006

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Our studies suggest that miR-183-5p may function as a tumor suppressor in lung cancer via the miR-183-5p/PIK3CA regulatory axis and identify a potentially effective therapeutic strategy for lung cancer. 30528264

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 AlteredExpression BEFREE Finally, we identified that the PI3K-AKT and epilthelial-mesenchymal transition (EMT) signaling pathways were inhibited by miR-3666 overexpression in lung cancer cells. 30481052

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE All of these results suggested that the lncRNA FER1L4 suppressed cell proliferation and metastasis by inhibiting the PI3K/Akt signaling pathway in lung cancer. 31115514

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Long non-coding RNA OECC promotes cell proliferation and metastasis through the PI3K/Akt/mTOR signaling pathway in human lung cancer. 31452780

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Therefore, targeting the PI3K pathway may be a potential therapeutic strategy that prevents the structural skeletal damage associated with bone metastasis of lung cancer. 30896825

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE TP53, EGFR and PIK3CA gene variations observed as prominent biomarkers in breast and lung cancer by plasma cell-free DNA genomic testing. 31100334

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE These results suggest that 27HC promotes lung cancer cell proliferation via ERβ and PI3K-Akt signaling. 30190703

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer. 29864375

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Fibroblast activation protein-α promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways. 29115573

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE The RAS-PI3K interaction is thus an important signaling node and potential therapeutic target in EGFR-mutant lung cancer, even though RAS oncogenes are not themselves mutated in this setting, suggesting different strategies for tackling tyrosine kinase inhibitor resistance in lung cancer. 30590030

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Moreover, MCMs and PHGDH can be poor prognostic factors for lung cancer. 29888431

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 AlteredExpression BEFREE Compared with those in the control group, expression of PI3K and Akt in the lung cancer cells H1299 after EGCG treatment showed no significant differences (p>0.05), while expression levels of p-PI3K and p-Akt were significantly reduced (p<0.05). 30058690

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3. 29504919

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE The mechanism may involve of PI3K/AKT signaling pathways in A549 cells, which may a potential therapeutic target for the treatment of lung cancer. 30344755

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE We firstly provide a preclinical evidence that acRoots can significantly inhibit lung cancer cell proliferation and apoptosis via the PI3K-OASL signal pathway. 29508110

2018