×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2 :c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma.
28514723 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.
27153395 2016
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
BEFREE
Such factors may not be needed for breast tumors with a defect in a non-essential gene such as CHEK2 .
26553136 2015
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
BEFREE
Development of breast tumors in CHEK2 , NBN/NBS1 and BLM mutation carriers does not commonly involve somatic inactivation of the wild-type allele.
24415413 2014
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
BEFREE
We found an even stronger significant association between the CHEK2 I157T C variant and increased risk of lobular type breast tumors (OR = 4.17, 95% CI = 2.89-6.03, P < 0.0001).
22799331 2012
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
22419737 2012
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
CLINVAR
CHEK2 contribution to hereditary breast cancer in non-BRCA families.
22114986 2011
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
BEFREE
We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC -mutation carriers.
21542898 2011
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations.
18930998 2009
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
CTD_human
Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines.
18297428 2009
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls.
19124502 2009
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Estrogen receptor status in CHEK2-positive breast cancers: implications for chemoprevention.
19021634 2009
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.
18706089 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.
18571837 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population.
18484200 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations.
18058223 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Absence of CHEK2 1100delC mutation in familial breast cancer cases from a South American population.
17876702 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls.
18172190 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Frequency of the CHEK2 1100delC mutation among women with breast cancer: an international study.
18381420 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation.
18175216 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Risk for contralateral breast cancer among carriers of the CHEK2*1100delC mutation in the WECARE Study.
18253122 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer.
18725978 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?
18557994 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
CLINVAR
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
17721994 2007
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.
18085035 2007