Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE Among the processes involved in the breast tumor microenvironment, angiogenesis and inflammation play a central role, and the main factors of these processes are the vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2) and macrophages. 29609579

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE Inducible cyclooxgenase-2 (COX-2) is commonly overexpressed in breast tumors and is a target for cancer therapy. 28666869

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE COX-2 modulates mammary tumor progression in response to collagen density. 27000374

2016

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE These data suggest that downregulation of RhoGDI could be a critical mechanism of breast tumor development, which may involve the hyperactivation of Rho GTPases and upregulation of COX-2 activity. 26416248

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE Furthermore, these results showed that LV-COX-2 combination with TAM is a potential drug candidate for treatment of breast tumors expressing high levels of VEGF. 24535190

2014

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 GeneticVariation BEFREE Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function. 24590894

2014

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors. 21683430

2012

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker BEFREE Overall, these data identify a new p130Cas/Cyclooxygenase-2 axis as a crucial element in the control of breast tumor plasticity, opening new therapeutic strategies leading to inhibition of these pathways in aggressive breast carcinoma. 23098208

2012

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE To elucidate the mechanisms by which exacerbated COX2 expression potentiates metastasis we genetically manipulated non-metastatic mammary tumor cells (TM40D) to over-express COX2 (TM40D-COX2). 23029485

2012

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE By immunocytochemistry, Western blotting and flow cytometry analysis, oestrogen treatment of R2d cells was found to induce many important effects related to breast carcinogenesis, namely: (i) the emergence of a subpopulation of cells expressing CD44+/high/CD24-/low breast tumour stem cell markers; (ii) the induction of EMT (epithelial-to-mesenchymal transition); (iii) the acquisition of metastatic ability; and (iv) the expression of COX-2 (cyclo-oxygenase-2) through a CD44-mediated mechanism. 19895368

2010

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE Up-regulation of COX-2 in ER-negative and HER2-positive breast tumors is associated with Akt pathway activation and is a marker of poor outcome. 21078168

2010

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression BEFREE High levels of the cyclooxygenase-2 (COX-2) protein have been associated with invasion and metastasis of breast tumors. 18386173

2009

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Cyclooxygenase-2 expression during immortalization and breast cancer progression. 18199541

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. 18190720

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN The malignant phenotype of breast cancer cells is reduced by COX-2 silencing. 18953425

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Glucocorticoid receptor changes its cellular location with breast cancer development. 17952860

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer. 18334709

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker CTD_human Cyclooxygenase-2 induces genomic instability, BCL2 expression, doxorubicin resistance, and altered cancer-initiating cell phenotype in MCF7 breast cancer cells. 18498876

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Tpl-2/Cot and COX-2 in breast cancer. 18795070

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Pathological analysis demonstrated that COX-2 overexpression was associated with CCR7, EP2, and EP4 expressions in breast tumor tissues. 18319253

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation. 18262731

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Cyclooxygenase-2 (COX-2) is associated with breast tumour progression. 18469157

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. 18192694

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker CTD_human [The effect of cyclooxygenase-2 on lymphangiogenesis in breast cancer]. 18509974

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Cyclooxygenase-2 induces genomic instability, BCL2 expression, doxorubicin resistance, and altered cancer-initiating cell phenotype in MCF7 breast cancer cells. 18498876

2008