Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker BEFREE One factor, which may drive ongoing matrix synthesis in breast tumors, is the loss of stromal caveolin-1 (cav-1), a scaffolding protein of caveolae, which has been linked to breast tumor aggressiveness. 28187162

2017
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 PosttranslationalModification BEFREE Cav1 CGI shore methylation was also observed in human breast tumors, and overall survival rates of breast cancer patients lacking estrogen receptor α (ERα) negatively correlated with Cav1 expression. 23128390

2013
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker CTD_human Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization. 21501481

2011
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker CTD_human Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling. 20562527

2010
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker CTD_human Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. 19288272

2010
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. 19234134

2009
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker CTD_human Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. 19234134

2009
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression BEFREE Importantly, in vivo experiments employing xenograft tumor models demonstrated that expression of caveolin-1 results in significant growth inhibition of breast tumors. 18778685

2008
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Caveolae/caveolin-1 are important modulators of store-operated calcium entry in Hs578/T breast cancer cells. 18296864

2008
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 PosttranslationalModification LHGDN Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity. 17190831

2007
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation. 17935714

2007
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Caveolin-1 expression is associated with a basal-like phenotype in sporadic and hereditary breast cancer. 16541313

2006
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Albumin-bound paclitaxel, ABI-007 may show better efficacy than paclitaxel in basal-like breast cancers: association between caveolin-1 expression and ABI-007. 16897435

2006
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer. 16244790

2006
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. 15592498

2005
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 PosttranslationalModification LHGDN Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers. 15375584

2004
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker BEFREE This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer. 15334058

2004
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer. 15334058

2004
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker BEFREE We investigated the function of caveolin-1 protein in breast tumors. 14506991

2003
Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker BEFREE Together our data refute a role for CAVEOLIN-1 as a breast tumour suppressor gene in vivo. 10086342

1999