Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Immune cells that infiltrate some types of HCCs secrete interferon gamma (IFNG). 31678303

2020

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Here, we aimed to investigate the interaction between IL-17 and IFN-γ and its influence on HCC cell apoptosis and growth in vitro and in vivo. 31784083

2020

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE IFN-γ was significantly higher in HCC than in other liver diseases (P < 0.01). 31053499

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE We further found that RIP3 knockdown results in an increase of MDSCs and a decrease of interferon gamma-positive (IFN-γ<sup>+</sup> ) cluster of differentiation 8-positive (CD8<sup>+</sup> ) tumor-infiltrating lymphocytes (IFN-γ<sup>+</sup> CD8<sup>+</sup> T cells) in hepatoma tissues, thus promoting immune escape and HCC growth in immunocompetent mice. 31021443

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Conclusion: This work demonstrates that NK cell-derived IFN-γ promotes HCC through the EpCAM-EMT axis in HBs-Tg mice, revealing the importance of innate immunity in pathogenesis of HBV-associated HCC. 30329167

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 GeneticVariation BEFREE The experiments were performed in 5 groups (phosphate buffered saline/PBS, BMSCs, BMSC-IFN-γ, BMSC-IL-10 and BMSC-IFN-γ-IL-10) and the genetically engineered BMSCs were transplanted into HCC mice. 29332347

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Augmentation of IFN-γ+ CD8+ T cell responses correlates with survival of HCC patients on sorafenib therapy. 31391334

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE The levels of IL-2, IFN-γ and TNF-α in HCC tumor tissues were also analyzed by ELISA. 31710117

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE Following treatment with Foxp3-shRNA, the average tumor volume, ratio of Tregs/CD4<sup>+</sup> T cells and level of IL-10, TGF-β and VEGF significantly decreased, however, the level of IFN-γ and IL-2 significantly increased compared with un-treated HCC mice (P<0.05). 29387180

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE MYC inhibition increases PD-L1 expression induced by IFN-γ in hepatocellular carcinoma cells. 30007230

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE More importantly, NK-92-S3KD immunotherapy increases the production of not only IFNγ, but also granzyme B and perforin in tumors; therefore, inhibiting cancer progression in two xenograft mouse models with human hepatoma (HepG2) and melanoma (A375). 29915022

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Incubation of CD8<sup>+</sup> T cells from HCCs with a discrete population of PD1-high cells with antibodies against PD1 and TIM3 or LAG3 further restored proliferation and production of IFNG and TNF in response to anti-CD3. 30145359

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE Significant correlations among IDO1, IFNG, and CD8A transcriptional levels were observed in freshly resected HCC specimens; moreover, no constitutive IDO1 expression was detected in HCC cell lines until stimulated by interferon-γ through the JAK2-STAT1 signaling pathway, but not type I interferon. 30264546

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE MDSC count was negatively correlated with IFN-γ levels, while α-FP was positively correlated with MDSC% in the HCC group. 29182438

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE IFN-γ induces up-regulation of galectin-9 and EZH2 in HCC cell lines. 29316949

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE A mixed Th1/Th2 cytokine pattern was induced, although a more predominant production of TNFα and IFNγ was observed in HCC patients versus healthy controls. 27832318

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE In addition, serum sFASL levels were significantly elevated in both HCV and HCC groups, whereas serum IFN-γ levels were only elevated in the HCC group. 28609212

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE T-cell responses were investigated by interferon-gamma (IFN-γ) enzyme-linked immunospot and cytotoxic T lymphocyte (CTL) assays using peripheral blood mononuclear cells (PBMCs) in 47 patients, and tumor-infiltrating lymphocytes in 8 of 47 patients with HCC. 28114424

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Therefore, targeting A20 enhances the cytotoxicity of IFN-γ against HCC cells and may present a promising therapeutic strategy for HCC. 29033545

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE Further, TGF-β and IFN-γ levels were higher and lower in patients with HCC or CHB, respectively. 28237828

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE CD133(+) HCC CSCs resisted IFN-γ-induced autophagy, which might also be a mechanism through which CSCs resist immune eradication. 26758620

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Soluble B7‑H4 (sB7‑H4), interferon‑γ (IFN‑γ), and interleukin‑4 (IL‑4) in blood serum were assessed using ELISA in patients with HCC and mice injected with tumor cells. 27840912

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Hep3B cells were transduced by HCC‑specific recombinant adeno‑associated virus (rAAV) carrying human α‑fetoprotein promoter (AFPp) and the interferon‑γ (IFN‑γ) gene (rAAV/AFPp‑IFN‑γ). rAAV carrying the cytomegalovirus promoter (CMVp) and human α‑fetoprotein (AFP) gene (rAAV/CMVp‑AFP) was used to transduce professional antigen‑presenting DCs for the purpose of stimulating a CTL response. 26936017

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Interferon regulatory factor-1 (IRF-1) is a tumor-suppressor gene induced by interferon-γ (IFNγ) and plays an important role in the cell death of hepatocellular carcinoma (HCC). 27279136

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 GeneticVariation BEFREE Interaction exists between the polymorphisms of IFN-γ and MICA, which may increase risk of HCC. 26893439

2016