Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE However, disease-specific meta-analysis showed an association between Wegener's granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95% CI = 0.547-0.971, p = 0.031). 26213801

2016

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 GeneticVariation BEFREE These are granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis) and microscopic polyangiitis (MPA). 24737903

2015

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener's granulomatosis). 24485158

2014

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 GeneticVariation BEFREE Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis, and primary sicca syndrome (pSS). 23073294

2013

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 GeneticVariation BEFREE These are granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis) and microscopic polyangiitis (MPA). 23606701

2013

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Furthermore, meta-analysis of the AA genotype, the AA and AG genotypes, and the A allele of TNF-α failed to reveal any association with Wegener's granulomatosis (WG). 21553055

2012

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE However, meta-analysis showed a significant association between the T allele and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) (OR 1.415, 95 % CI 1.228-1.630, p = 1.59 × 10(-6)) and Wegener's granulomatosis (WG) (OR 1.829, 95 % CI 1.377-2.431, p = 3.09 × 10(-5)). 22696186

2012

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 GeneticVariation BEFREE Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). 22247758

2012

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. 22808956

2012

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Wegener's granulomatosis (WG) is a complex autoimmune disease of unknown etiology, frequently involving localized inflammation of the nasal mucosa as an early manifestation. 21412229

2011

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE In patients with Wegener's granulomatosis (WG) who were PR3-ANCA positive, DRB1*1202 (8/38 vs 20/400, p = 1.3 × 10(-3), p(c) = 0.047) was more prevalent than in normal controls. 21354458

2011

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Deficiency of α(1) -antitrypsin (α(1) AT) may be a determinant of susceptibility to Wegener's granulomatosis (WG). 20827781

2011

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Proteinase 3 (PR3)-specific antineutrophil cytoplasmic antibodies (ANCA) are highly specific for the autoimmune small vessel vasculitis, Wegener's granulomatosis (WG). 20810247

2011

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 GeneticVariation BEFREE Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases, such as rheumatoid arthritis (RA), Graves' Disease (GD), systemic lupus erythematosus (SLE), Wegener's granulomatosis (WG) and type 1 diabetes mellitus (T1D). 21467606

2011

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 PosttranslationalModification BEFREE The etiology of Wegener's granulomatosis (WG) is unknown. 20889595

2011

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Wegener's granulomatosis (WG), characterized by systemic vasculitis and granulomatous inflammation, is a rare chronic rheumatic condition potentially sharing some etiopathological principles with other autoimmune disorders, e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). 20049410

2010

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE In Wegener's granulomatosis (WG), vasculitic lesions are characterized by prominent infiltration of polymorphonuclear neutrophils (PMN) and T cells, but underlying pathogenic mechanisms remain to be defined. 19797511

2010

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Wegener's granulomatosis (WG) is a systemic inflammatory disease that is associated with substantial morbidity. 20155833

2010

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Their role in Wegener's granulomatosis (WG) are, however, poorly recognized. 19514647

2009

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 GeneticVariation BEFREE Here we present evidence that this polymorphism also predisposes to Wegener's granulomatosis (WG), an autoimmune condition belonging to the group of ANCA (antineutrophil cytoplasmic autoantibody)-associated vasculitides. 19536154

2009

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Wegener's granulomatosis (WG) is a rare disease with unknown aetiology, but there is evidence for a complex genetic background. 18799058

2009

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Here we aim to investigate whether these functional polymorphisms contribute to other eight chronic inflammatory diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Wegener' granulomatosis (WG), Churg-Strauss syndrome (CSS), Crohn's disease (CD), ulcerative colitis (UC), primary sclerosing cholangitis (PSC) and psoriasis. 19387457

2009

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Increased amounts of anti-neutrophil cytoplasm antibody (ANCA) directed against proteinase 3 (PR3) are a diagnostic and pathogenic hallmark of full-blown Wegener's granulomatosis (WG). 18826496

2009

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Hence, in this study, our main objective is to evaluate the association of PDCD1 gene to Wegener's granulomatosis (WG). 19449188

2009

Entrez Id: 474168
Gene Symbol: WG
WG
CUI: C3495801
Disease: Granulomatosis with polyangiitis
Granulomatosis with polyangiitis
0.100 Biomarker BEFREE Wegener's granulomatosis (WG) is characterized by granulomatous inflammation of the respiratory tract and Anti Neutrophil Cytoplasmic Antibody (ANCA)-associated systemic vasculitis. 18799062

2009