Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE Disruption of IQGAP1-scaffolded PI3K/AKT signaling reduced HNC cell survival. 31597661

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer. 31785230

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE We found that PI3K regulatory subunit p85 was predominantly phosphorylated in radioresistant head and neck cancer cell line (HN31), which showed resistance to PI3K inhibitors. 29496059

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 GeneticVariation BEFREE A Pilot Study to Non-Invasively Track PIK3CA Mutation in Head and Neck Cancer. 30501041

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 AlteredExpression BEFREE Moreover, MSC-CM promoted the expression of POSTN and POSTN promoted HNC progression through the activation of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway. 29284199

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. 29440171

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer. 28197389

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 AlteredExpression BEFREE These observations suggest that TrkB is a promising target for future intervention strategies to prevent tumor metastasis, EMT program in laryngeal cancer.What is already known about this subject?• Cancer of the larynx is one of the most common types of head and neck cancer.• The survival rate of advanced laryngeal cancer is only 30 to 40%.• The tropomyosin-related kinase B receptor (TrkB), together with TrkA and TrkC, are neurotrophin receptors regulating the proliferation and differentiation of neuronal cells.What are the new findings?• TrkB are overexpressed in laryngeal cancer.• TrkB signaling is involved in tumorigenicity of laryngeal cancer.• TrkB acts as a key regulator of the PI3K/AKT signal pathway-mediated tumor metastasis.How might these results change the focus of research or clinical practice?• These observations suggest that TrkB is a promising target for future intervention strategies to prevent tumor metastasis, EMT program in laryngeal cancer. 29312563

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 AlteredExpression BEFREE Computational analysis indicated that miR-296-3p targeted PTEN, which regulates the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and PTEN is involved in the carcinogenesis of SCC. miR-296-3p directly regulated PTEN expression in head and neck cancer cells, with PTEN protein levels decreased in 4/19 the SCCs (21.0%), as compared with those in the IPs (76.4%). 28693263

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE PIK3CA and MET may play an important role in oncogenesis of certain specific subtypes of head and neck cancer. 26832731

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE Our findings reveal a new mechanism by which EGFR/PI3K/Akt/mTOR signaling promotes head and neck cancer progression and underscores the need for developing a therapeutic strategy for targeting IKK/NF-κB either as a single agent or in combination with cisplatin in head and neck cancer. 26895469

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE Inhibition of the PI3K/Akt pathway decreases hypoxia within SQ20B human head and neck cancer xenografts. 25995437

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies. 24219320

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 AlteredExpression BEFREE Activation of PIK3CA downstream targets and sensitivity to pathway inhibitors were determined in HPV(+) head and neck cancer cells overexpressing wild-type or mutant PIK3CA. 24599934

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. 23619167

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 AlteredExpression BEFREE PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer. 23640975

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 Biomarker BEFREE Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. 23847349

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 GeneticVariation BEFREE We previously reported 4 PIK3CA mutations in 38 head and neck cancer samples, 3 of which were identified in 6 pharyngeal cancer samples. 17990317

2008

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.400 CausalMutation CGI