Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE CacyBP/SIP promoted the cell proliferation of colon cancer cells under both basal and gastrin stimulated conditions as shown by knockdown studies. 28196083

2017

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Gastrin inhibited proliferation of colon cancer cells by suppressing expression of EGR1 and AE2 and by blocking ERK phosphorylation. 22228178

2012

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 PosttranslationalModification BEFREE The promoter of somatostatin (SST), a primary inhibitor of gastrin-stimulated gastric acid secretion, is hypermethylated in 80% of human colon cancers. 17999418

2008

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production. 15655524

2005

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE While epidemiological evidence from patients with elevated serum gastrin levels related to pernicious anaemia does not support an increased risk for colon cancer, a recent study suggests that prolonged hypergastrinaemia is associated with an increased risk for colon cancer. 11589724

2001

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Our findings show that physiological doses of incompletely processed form of gastrin induce the invasiveness of tumor cells in vitro and suggest a novel potential role for this peptide in the metastatic process of colonic cancers in vivo. 11437383

2001

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE The growth of colon cancer was promoted by the application of gastrin, whereas it was restricted by proglumide, which is known to be a gastrin receptor antagonist. 11876552

2001

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Previous studies have shown that the gene encoding the hormone gastrin is activated during colon cancer progression and the less-processed forms of gastrin are important colonic trophic factors. 10953028

2000

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE The expression of COX Vb by colon cancer cells was proportional to the expression of gastrin. 10915781

2000

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE This suggests that glycine-extended gastrin and its novel receptors may play a role in colon cancer cell growth. 10404512

1999

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Colon cancer cell lines and tissues with K-ras mutations all had significantly higher gastrin mRNA levels than those that were ras wild type. 9797369

1998

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Thus low to moderate levels of gastrin were expressed by human colon cancer cell lines which may function as autocrine growth factors for colon cancers. 7509020

1994

Entrez Id: 2520
Gene Symbol: GAST
GAST
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE To investigate the hypothesis that gastrin might be synthesized by tumour tissues in cancer of the colon, samples from six human colon tumours, one hepatic metastasis, four normal colonic mucosal samples and two antral and one fundic gastric mucosal samples from nine patients were analysed to determine whether gastrin mRNA was present. 7507679

1993