Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.330 GeneticVariation BEFREE IκBKβ's rs6474387 (C>T intron 20) and rs11986055 (A>C intron 2) showed substantially lower colon cancer risk among current NSAID users (P(interaction) = 0.01 and P(interaction) = 0.045, respectively), whereas NFκB1's rs230490 (G>A 5' (outside UTR)) and rs997476 (C>A 3' (outside UTR)) showed higher CRC risk among current NSAID users (P(interaction) = 0.01 and P(interaction) = 0.03, respectively). 23002237

2013

Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.330 GeneticVariation BEFREE The most significant finding (nominal P = 0.0004; false discovery rate q = 0.037) was a combined genotype association across IKBKB SNP rs5029748 (1 or 2 variant alleles), IL6 rs1800797 (1 or 2 variant alleles), and NFKB1 rs4648110 (2 variant alleles) which conferred an ~80% decreased risk of colon cancer. 21129206

2010

Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.330 AlteredExpression BEFREE Inflexinol inhibits colon cancer cell growth through inhibition of nuclear factor-kappaB activity via direct interaction with p50. 19509257

2009