Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Effect of NF-Bp65 inhibitor (BAY-117082) on the proliferation and expression level of Cyclin D1 and PLD2 of colon cancer cells under hypoxic conditions were further analysised. 30091007

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Curcumol caused cell cycle arrest at the G0/G1 phase by ROS production and Akt/ GSK3β/cyclin D1 pathways inactivation, indicating the potential of curcumol in the prevention of colon cancer carcinogenesis. 28684297

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Fluorescence in situ hybridization analysis confirms the expression of CCND1 in colon cancer while immunofluorescence analysis confirms the CDK4 in diabetes. 30462152

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE As revealed by Western blot, the expression of CDK2 and Cyclin D1 was down-regulated in all three Vglycin-treated colon cancer cells, indicating that the CDK2/Cyclin D1 cell cycle pathway involved in the initiation and progression of colon cancer. 28492347

2017

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway. 27191497

2016

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE The cyclin D1 (CCND1) rs9344 G>A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy. 23567490

2014

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE In light of these observations, we investigated the association of T-Antigen and nuclear β-catenin in colon cancer cases and the effects of this complex in the activation of the transcription and cell cycle regulators c-Myc and Cyclin D1 in vitro. 25229241

2014

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE The downstream genes regulated by miR-147 were assayed using the Affymetrix GeneChip U133 Plus2.0 platform. miR-147 was identified to: 1. cause MET primarily by increasing the expression of CDH1 and decreasing that of ZEB1; 2. inhibit the invasion and motility of cells; 3. cause G1 arrest by up-regulating p27 and down-regulating cyclin D1. miR-147 also dramatically reversed the native drug resistance of the colon cancer cell line HCT116 to gefitinib. miR-147 significantly repressed Akt phosphorylation, and knockdown of Akt with siRNA induced MET. 24454732

2014

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Hath1 inhibits proliferation of colon cancer cells probably through up-regulating expression of Muc2 and p27 and down-regulating expression of cyclin D1. 23464457

2012

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In conclusion, we demonstrated that SCC-S2 is overexpressed in colon cancers and contributes to malignant cell growth by cyclin D1 and phospho-Rb modulation, which makes SCC-S2 a candidate therapeutic target in colon cancer. 22886548

2012

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE In conclusion, our study found that CARMA3 is overexpressed in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NF-κB mediated upregulation of cyclin D1. 22884800

2012

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE The results showed that small interfering RNA directed against β-catenin markedly inhibited the expression and nuclear translocation of β-catenin and decreased the expression of known target genes such as cyclin D1 and c-myc; HT-29 cell proliferation was inhibited as indicated by growth reduction, cell cycle arrest in G0/G1 phase, and induction of apoptosis; and the inhibition of cell growth may be associated with switching off cyclin D1 and c-myc expression by small interfering RNA targeted against β-catenin in colon cancer HT-29 cells. 20950152

2010

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Forty-eight-hour treatment of colon cancer HCT-116 and HT-29 cells with FOLFOX resulted in 60-70% survival, accompanied by a marked activation of insulin like growth factor-1 receptor (IGF-1R) and minor to moderate increase in epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (HER-2) as well as v-akt murine thymoma viral oncogene homolog 1 (AKT), cyclooxygenase-2 (COX-2) and cyclin-D1. 20332435

2010

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. 19440933

2009

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Collectively, this study demonstrates that over-expression of DIXDC1 might target p21 and cyclin D1 to promote colon cancer cell proliferation and tumorigenesis at least partially through activation of the PI3K/Akt pathway. 19572978

2009

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Previous studies have identified cyclin D1 as a major target in the antiproliferative effects of PKCalpha in non-transformed intestinal cells; however, a link between PKC signaling and cyclin D1 in colon cancer remained to be established. 19232344

2009

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE While APC/beta-CATENIN-dependent expression of CYCLIN D1 was observed in vivo and in vitro, expression of PPAR beta/delta was not different in colon or intestinal polyps from wild-type or Apc(min) heterozygous mice or in human colon cancer cell lines with mutations in APC and/or beta-CATENIN. 19415698

2009

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Cyclin D1 overexpression is associated with longer survival in colon cancer. 19549773

2009

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Our results show that low concentrations of DCA (5 and 50 microM) significantly increase tyrosine phosphorylation of beta-catenin, induce urokinase-type plasminogen activator, uPAR, and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness. 15004225

2004

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE Whereas our data do not support a modifying role of A versus G allele of CCND1, the results do suggest that the relative abundance of a and b transcripts may modify the age at onset of colon cancer in hereditary nonpolyposis colorectal cancer. 11507050

2001