Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE In particular, the PC-loaded EFM exerted its anti-cancer activity by blocking the cell cycle at the G0/G1 phase and inducing cell apoptosis involving the decrease of Bcl-2/Bax, activation of caspase 3 and release of cytochrome c. This study suggests that co-axial electrospinning is an efficient and effective way to deliver PC and improve its bioavailability; thus, it represents a promising approach for encapsulating functional ingredients for colon cancer prevention. 30806395

2019

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE Collectively, our results revealed that ZEB2-AS1 was upregualted and functioned as an oncogene via regulating miR-143/bcl-2 axis in colon cancer. 31497237

2019

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE Emodin activated caspases, modulated Bcl-2 family of proteins and reduced mitochondrial membrane potential to induce CoCa cell death. 31011292

2019

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE To investigate the molecular mechanisms of cordycepin against colon cancer and in driving apoptosis, p53 and Bcl‑2‑like protein 4‑null (Bax‑/‑) colon cancer HCT116 cell lines were used. 30535479

2019

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE We have demonstrated the therapeutic potential of miR-15a in colon cancer. miR-15a inhibits several important genes (<i>BCL2, BMI1, YAP1</i> and <i>DCLK1</i>), decreasing cancer progression and resistance. 29416778

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE The present study aimed to explore the role of B-cell lymphoma 2 (BCL-2) in promoting colon cancer development associated with LIN28B. 29669301

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE Targeting Bcl-2 proteins via DZNep or BH3 mimetics could increase the therapeutic potential of MDM2-antagonists like Nutlin-3a in colon cancer. 29394130

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE The expressions of C-MYC and BCL-2 in colon cancer tissues exhibited high levels of expression, while miR-184 displayed relatively low levels in comparison to the adjacent normal tissues. 28782841

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE This investigation was conducted to construct a hypoxia/colorectal dual-specific bidirectional short hairpin RNA (shRNA) expression vector and to transfect it into the colon cancer cell line HT-29 with PEI/chitosan-TBA nanoparticles for the simultaneous knock down of β-catenin and Bcl-2 under hypoxia. 29656061

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE Using HCT-116 human colon cancer cell line, expression of AMPK, extracellular signal-regulated kinase (ERK), cyclin D1, and Bcl-2 was investigated and cell cycle arrest was assessed. 27845068

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. 25548100

2015

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE Exosome-Carried microRNA-375 Inhibits Cell Progression and Dissemination via Bcl-2 Blocking in Colon Cancer. 26697569

2015

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE Silencing of miR-210 upregulated Bcl-2 expression and reduced the survival fraction of colon cancer cells after radiation treatment. 25385144

2015

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE Virosecurinine induces apoptosis by affecting Bcl-2 and Bax expression in human colon cancer SW480 cells. 22570942

2012

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE High expressions of Bag-1 and Bcl-2 proteins in colon cancer were found. 20409521

2010

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE The loss of Bcl-2 expression appears to be correlated with increase in number of relapses in the stage II colon cancers and could be a potential useful additional histo-prognostic marker in therapy decision making. 19027288

2009

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE Our results indicate that early apoptosis and cell death of human colon cancer cells induced by photodynamic therapy with lysosome-localizing photosensitizer ATX-S10Na (II) are mediated by p53-Bax network and low levels of Bcl-2 and Bcl-x(L) proteins. 17278191

2007

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE Bcl-XL, an anti-apoptotic protein of Bcl-2 family, is overexpressed in colon cancers. 17534896

2007

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX. 17426704

2007

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE Expression of cell survival/death genes: Bcl-2 and Bax at the rate of colon cancer prognosis. 15955446

2005

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE We examined whether 5F could affect apoptosis in human colon cancer HT-29 cells, and test whether and how the over-expression of Bcl-2 and Bcl-xL could offset the effect of 5F on cell growth. 15314290

2004

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE This study suggested that a PPARgamma-Bcl-2 feedback loop may function to control the life-death continuum in colonic cells and that a deficiency in generation of PPARgamma ligands may precede the development of human colon cancer. 12269390

2002

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status. 11920608

2002

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression BEFREE Down-regulation of Bcl2 expression might represent a potential mechanism by which ASA induces apoptosis in this COX-2 negative colon cancer cell line. 12423325

2002

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker BEFREE Transfection of the sialidase gene into colon cancer cells inhibited apoptosis and was accompanied by increased Bcl-2 and decreased caspase expression. 12149448

2002