Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.560 GeneticVariation BEFREE The association of XPC rs2229090 was more apparent in adenocarcinoma than in squamous cell carcinoma patients. 28878296

2017

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.560 AlteredExpression BEFREE However, levels of XPC or DDB2 proteins or both were variably reduced in repair-deficient SCC cell lines. p53 levels did not correlate with DNA repair activity or with XPC and DDB2 levels, but p63 levels were deficient in cell lines with reduced global repair. 27499003

2016

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.560 GeneticVariation BEFREE Genome-wide evidence of XPC alteration in laryngeal squamous cell carcinomas. 22126485

2011

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.560 GeneticVariation BEFREE Loss or mutation of XPC may be an early event during skin carcinogenesis that provides a selective advantage for initiation and progression of squamous cell carcinomas in non XP-C patients. 20616346

2010

Entrez Id: 7508
Gene Symbol: XPC
XPC
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.560 GeneticVariation BEFREE These results suggest that the XPC PAT+polymorphism does not play a major role in non-melanoma skin cancer, but that it may slightly modify the risk of SCC among individuals with a phenotype which results in low UV-DNA adduct burdens. 15863269

2005