Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Computed tomography (CT)-reported T stage, CT-reported LN status, preoperative tumour differentiation, carcinoembryonic antigen, carbohydrate antigen 19-9 and TSP were independent predictors of LN metastasis in CRC. 31787749

2020

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Therefore, we recommend routinely performing ascites CEA analysis in colorectal cancer surgery. 31802190

2020

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The serum B7-H3, B7-H1, cancer-associated carbohydrate antigen-50 (CA-50) and carcinoembryonic antigen (CEA) expressions in patients with CRC, benign gastrointestinal diseases, and healthy controls were measured by ELISA. 31424670

2020

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Carcinoembryonic antigen (CEACAM5, CEA) is a known tumor marker for colorectal cancer that localizes in a polarized manner to the apical surface in normal colon epithelial cells whereas in cancer cells it is present at both the apical and basolateral surfaces of the cells. 29304557

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Biomarkers currently used in clinical practice, including carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9, lack sufficient sensitivity and specificity for early diagnosis and prediction, therefore there remains a requirement to improve the prognosis of patients with CRC. 31423284

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Older age, male sex, African-American race, elevated CEA and not undergoing curative surgery were independent risk factors of cardiovascular mortality in patients with colorectal cancer. 30604158

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Age (p = 0.010), tumor size (p < 0.001), T stage (p < 0.001), N stage (p < 0.001), race (p < 0.001), tumor site (p < 0.001), liver metastasis (p < 0.001), brain metastasis (p < 0.001), bone metastasis (p < 0.001), serum levels of carcinoembryonic antigen (CEA) (p < 0.001), and circumferential resection margin (CRM) (p < 0.001) were associated with a risk of LM from CRC. 30854572

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Both S100A9 and TNC levels were superior to CEA and CA19-9 levels as CRC diagnostic biomarkers; the combination of S100A9, TNC and CEA levels was an excellent biomarker with 79.8% sensitivity and 89.6% specificity. 31632476

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE There was no correlation between serum <i>β</i>-catenin levels and CEA in CRC patients (<i>P</i> = 0.14). 31781302

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Patients from the three groups differed in terms of location of CRC (P = 0.034) and carcinoembryonic antigen (CEA) level (P = 0.036). 30776583

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Effects of vitamin D and omega-3 fatty acids co-supplementation on inflammatory biomarkers, tumor marker CEA, and nutritional status in patients with colorectal cancer: a study protocol for a double blind randomized controlled trial. 31815661

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Moreover, Six-gene Assay was more sensitive and accurate than CEA Gene Assay in diagnosing CRC as well as predicting the 2-year PFS of CRC patients. 30556647

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Physiologically Based Modeling of the Pharmacokinetics of "Catch-and-Release" Anti-Carcinoembryonic Antigen Monoclonal Antibodies in Colorectal Cancer Xenograft Mouse Models. 30321546

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Besides, FPR, NLR, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA199) were markedly associated with differentiation of benign disease and CRC in the logistic regression analysis. 30047185

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE A preoperative CEA level can be an independent prognostic factor for stage I-III CRC after curative resection. 30915591

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE In this study, weight loss, body mass index, skeletal muscle index (SMI), serum carcinoembryonic antigen, serum tumor necrosis factor (TNF)-α, serum interleukin (IL)-6, serum high mobility group box (HMGB)-1, and SDS-soluble myosin light chain 1 (SDS-MYL1) of the psoas muscle were examined in 8 autopsied cases of death from colorectal cancer (CRC) as biomarkers of cachexia. 31707381

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The carcinoembryonic antigen (CEA) is the main tumor-associated antigen of colorectal cancers. 30770895

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE These reasons motivated the production of CEA-targeted nanotechnologies for monitorization of CRC progression, but only a few centers have reported their use for drug delivery. 30670480

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The risk of death during the long-term follow-up period was independently related to the clinical stage of CRC, impairment of the patient's functional status, and higher blood carcinoembryonic antigen concentration. 31747664

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE BACKGROUND Type 2 diabetes mellitus (T2DM) is related to the serum carcinoembryonic antigen (CEA) level, which is used as a marker of colorectal cancer. 31086125

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The higher serum CEA level than that of healthy individuals led to its clinical application as a diagnostic biomarker for colorectal cancer. 30905451

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE According to our prognostic model with 2 prognostic factors, the OS and DFS rate increased to 76.2% and 80.63%, respectively, in patients with high 18p TERRA expression and CEA levels ≤5 (P = .178, P = .057, respectively).18p TERRA expression was marginally significantly associated with preoperative CEA and significantly associated with telomere length, rendering it a potential prognostic factor for long-term oncologic outcomes in CRC. 30946316

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Carcinoembryonic antigen (CEA) is a commonly used biomarker in colorectal cancer. 31543685

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE In vivo, a murine surrogate of HERA-CD40L-stimulated clonal expansion of OT-I-specific murine CD8 T cells and showed single agent antitumor activity in the CD40 syngeneic MC38-CEA mouse model of colorectal cancer, suggesting an involvement of the immune system in controlling tumor growth. 30273198

2019

Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Overall, CEA remains a reliable predictor of recurrence and survival after curative surgery in patients with colorectal cancer. 30822523

2019