Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 GeneticVariation BEFREE BRAF inhibitor vemurafenib, and subsequent MAPK pathway inhibitors trametinib and SCH772984, significantly increased SPINK1 secretion in V600E CRC cell lines Colo205 and HT-29 with a concomitant decrease in trypsin-1 and -2 secretion. 29193645

2018
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 Biomarker BEFREE The role and association between SPINK1, EGFR and Ki-67 in colorectal adenoma (CRA) and colorectal cancer (CRC) are still unknown. 26037168

2015
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 AlteredExpression BEFREE Thus, PSTI expression is widespread in colorectal cancer, and occurs more commonly in advanced cases. 2257226

1990