Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of PGC-1α gene with type 2 diabetes in three unrelated endogamous groups of North-West India (Punjab): a case-control and meta-analysis study. 29063962

2018

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE PPARGC1A rs3736265 G>A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level. 28418876

2018

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Haplotype-based interaction of the PPARGC1A and UCP1 genes is associated with impaired fasting glucose or type 2 diabetes mellitus. 28591028

2017

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Metabolic roles of PGC-1α and its implications for type 2 diabetes. 25753246

2016

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In a large sample of the Caucasians the rs8192673 of the PGC-1α gene and the rs1801282 of the PPAR-γ gene were associated with waist circumference in subjects with T2DM. 25928419

2016

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins. 25977930

2016

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The rs2454206" genes_norm="54790">p.Ile1762Val substitution (TET2-rs2454206) was associated with liver PPARGC1A-methylation and transcriptional levels, and Type 2 diabetes.Our results suggest that 5-hmC might be involved in the pathogenesis of NAFLD by regulating liver mitochondrial biogenesis and PPARGC1A expression. 26356709

2015

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE PGC-1α plays a central role in hepatic gluconeogenesis and has been implicated in the onset of type 2 diabetes. 25497092

2015

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Furthermore, our research pinpoints the role of several new T2D-associated genes (such as Srebf1 and Ppargc1) in the human population. 25758573

2015

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association between PGC-1alpha gene polymorphisms and type 2 diabetes risk: a case-control study of an Iranian population. 25282005

2015

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE The effect of exercise on epigenetic modifications of PGC1: The impact on type 2 diabetes. 24703492

2014

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes. 24359475

2014

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 PosttranslationalModification BEFREE Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes? 23505498

2013

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Our results demonstrated that a novel small molecule selectively elevated the expression of PGC-1α in myotubes and skeletal muscle and exerted promising therapeutic effects for treating type 2 diabetes. 23250358

2013

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population. 22391941

2013

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPARγ on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes. 23426382

2013

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE At baseline, no differences were observed in NRF1-density between the T2DM men and the CON, while the contents of PGC1α and TFAM were decreased in the T2DM men. 23210442

2013

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus. 22684233

2012

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Collectively, we propose FGFR1 in adipose tissues as a major functional receptor for FGF21, as an upstream regulator of PGC-1α, and as a compelling target for antibody-based therapy for type 2 diabetes and other obesity-associated disorders. 22174314

2012

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes. 20175989

2011

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Effects of the peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) Thr394Thr and Gly482Ser polymorphisms on rosiglitazone response in Chinese patients with type 2 diabetes mellitus. 20498286

2011

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene polymorphisms and type 2 diabetes mellitus: a meta-analysis. 21294239

2011

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Patients with T2DM had significantly increased 8-OHdG and TUNEL labeling index and non-significant increases in the expression of PGC1-α and Tfam. 21281975

2011

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity. 20032281

2010

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Evidence for interaction between PPARG Pro12Ala and PPARGC1A Gly482Ser polymorphisms in determining type 2 diabetes intermediate phenotypes in overweight subjects. 19536736

2010