Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE Since many individuals with type 2 diabetes appear to have an inadequacy or defect in one or both of these processes, identifying compounds that can activate GK could provide a therapeutic benefit. 31818630

2020

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Islet ATAC-seq peaks overlap with 13 SNPs associated with T2D (e.g. rs7903146, rs2237897, rs757209, rs11708067 and rs878521 near TCF7L2, KCNQ1, HNF1B, ADCY5 and GCK, respectively) and with additional 67 SNPs in LD with known T2D SNPs (e.g. 31123324

2019

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE The clinical characteristics of patients with GK-activating mutations or GK regulatory protein (GKRP) loss-of-function mutations suggest that a hepatoselective GK activator (GKA) that does not activate GK in β cells or affect the GK-GKRP interaction may reduce hyperglycemia in patients with type 2 diabetes while limiting hypoglycemia and liver-associated adverse effects. 30651321

2019

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE TTP399 is a hepatoselective, glucokinase activator with potential for treating type 2 diabetes. 31398075

2019

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 AlteredExpression BEFREE Furthermore, 200 and 500 mg kg-1 d-1 ARs significantly increased the content of hepatic glycogen and the activity of glucokinase (p < 0.01) in T2DM mice. 31094396

2019

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE The N-pyridin-2-yl benzamide analogues discovered in the current study can provide some lead molecules for the development of potent oral GK activators with minimum side-effects for the management of type 2 diabetes. 30369030

2019

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE To estimate the prevalence of glucokinase variant-induced diabetes (GCK-DM) in a general population and to establish a clinical strategy for identifying GCK-DM from type 2 diabetes (T2DM). 30245511

2019

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE The APOE<sup>∗</sup>3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis. 30949516

2019

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We have previously identified a mutant GK (R308K) in patients with type 2 diabetes with reduced enzyme activity. 30087826

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE Allosteric activators of GK (GKAs) have the potential to treat type 2 diabetes mellitus. 30006171

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE The effect of arc GK was maintained in a model of type 2 diabetes. 29748994

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Adult-onset, or type II diabetes mellitus (T2DM) has a complex genetic architecture, from hundreds of genes with low penetrance, common susceptibility variants (e.g., TCF7L2), to a set of more than ten genes that, when mutated, can cause a single-gene or Mendelian form of T2DM (e.g., GCK). 29458357

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE To investigate the pharmacokinetics and pharmacodynamics of a dual-acting glucokinase activator, dorzagliatin, and its safety, tolerability and effect on pancreatic β-cell function in Chinese patients with type 2 diabetes (T2D). 29707866

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE In participants with GCK-MODY, treatment cessation was universally successful, with no change in HbA<sub>1c</sub> at follow-up. 30229274

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE It is demonstrated for the first time that dietary ANC can enhance the activity of novel biomarkers FFAR1 and GK and potentially ameliorate type-2 diabetes comorbidities. 29995924

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE These newly synthesized thiazol-2-yl benzamide derivatives thus can be treated as the initial hits for the development of new, safe, effective and orally bioavailable GK activators as therapeutic agents for the treatment of type 2 diabetes. 29518630

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE This study aimed to investigate differences in serum miR-122 levels in Chinese patients with different forms of diabetes, including T2DM, type 1 diabetes (T1DM), HNF1A variant-induced diabetes (HNF1A-DM), glucokinase variant-induced diabetes (GCK-DM), and mitochondrial A3243G mutation-induced diabetes (MDM). 30155490

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Most (6/7) patients with HNF4A variants rapidly failed TODAY treatment across study arms (hazard ratio = 5.03, P = 0.0002), while none with GCK variants failed treatment.ConclusionThe finding of 4.5% of patients with monogenic diabetes in an overweight/obese cohort of children and adolescents with T2D suggests that monogenic diabetes diagnosis should be considered in children and adolescents without diabetes-associated autoantibodies and maintained C-peptide, regardless of BMI, as it may direct appropriate clinical management. 29758564

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE This case highlights the value of sequencing the GCK gene in individuals with GCK-MODY phenotype and no family history of monogenic diabetes. 30086370

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE Glucokinase activators had been reported as one kind of new potential drugs for treatment of type 2 diabetes. 29477658

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 AlteredExpression BEFREE Here, we analyze human islets from individuals without or with T2D, using TaqMan-based real-time qPCR at the tissue (isolated islet) level as well as at single cell resolution, to assess the relationship between miR-206 and GCK expression in normal and T2D human islets. 29989852

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE Maturity onset diabetes type 2 [MODY2 (#125851)] caused by mutations in the glucokinase gene (GCK). 29056535

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE Heterozygous inactivating mutations in GCK are associated with defects in pancreatic insulin secretion and/or hepatic glycogen synthesis leading to mild chronic hyperglycaemia of maturity onset diabetes of young type 2 (MODY2). 30257192

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Although the influence of a common variant in the glucokinase regulatory gene (GCKR rs780094) in type 2 diabetes mellitus has been well documented, less data however, is available of its role in gestational diabetes mellitus (GDM). 29410004

2018

Entrez Id: 2645
Gene Symbol: GCK
GCK
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker BEFREE Author Correction: Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus. 29670171

2018