Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus. 24549597

2015

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of the 223A/G LEPR polymorphism with serum leptin levels in Iranian subjects with type 2 diabetes. 24206404

2014

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE PTP1B's direct regulation of the insulin and the leptin receptors makes it an ideal therapeutic target for type II diabetes and obesity. 23879520

2014

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of rs9939609 variant with higher FBG, plasma insulin, and leptin levels indicates that this polymorphism may disturb the metabolism in adult females and predispose them to obesity and type 2 diabetes. 24102053

2014

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Moreover, it is believed that leptin level deductions might be the cause of obesity and may play an important role in the development of Type 2 Diabetes Mellitus (T2DM), as well as in cardiovascular diseases (CVD). 24051404

2014

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE This study was designed to assess the role of soluble leptin and LepRb in NAFLD and to investigate whether leptin receptor gene (LepR) single nucleotide polymorphism (SNP; ID rs6700896) influences NAFLD complicated with or without type 2 diabetes mellitus (T2DM). 22215535

2012

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE A population of 1,974 White European individuals at increased risk for type 2 diabetes was characterized by an oral glucose tolerance test with glucose and insulin measurements (1,409 leptin measurements) and genotyped for five tagging SNPs covering 100% of common genetic variation (minor allele frequency ≥ 0.05) in the SERPINF1 locus. 22457810

2012

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Low levels of adiponectin, IGF-binding protein 1 (IGFBP1) and IGFBP2 and high levels of leptin correlate with several indices of insulin resistance and risk of type 2 diabetes. 22189999

2012

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE The mean plasma leptin levels in the T2DM group were significantly higher than that of controls and the plasma levels of leptin were higher in diabetic patients with macroangiopathy than in patients without macroangiopathy (P < 0.05). 21938427

2012

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE The recently described BTBR ob/ob (leptin deficient) mouse with Type II diabetes demonstrates key features of early podocyte loss and mesangiolysis characteristic of human diabetic nephropathy. 21422926

2011

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE These results identify a novel molecular pathway by which leptin confers inhibitory action on insulin secretion, and impaired PP-1 inhibition by leptin may be involved in dysfunction of the adipoinsular axis during the development of hyperinsulinemia and type 2 diabetes mellitus. 21427225

2011

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE The impact of obesity and obesity-associated type 2 diabetes as well as the potential regulatory role of insulin and leptin on aquaglyceroporins (AQP) 3, 7, and 9 were analyzed. 21289260

2011

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Therefore, orexin receptor controlling hypothalamic insulin/leptin actions may be a new target for possible future treatment of hyperglycaemia in patients with type 2 diabetes. 19489767

2010

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In subjects with and without type 2 diabetes, rs2016520 was associated with body mass index, high-density lipoprotein cholesterol, leptin, and TNFalpha and was dependent on gender. 20200337

2010

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Maternal and paternal family history of T2DM may have an additive impact on leptin, but not on adiponectin levels independent of adiposity and insulin sensitivity in overweight Latino children. 19183309

2009

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE This study suggests that DNA variants in ABCC8, ADIPOQ, IGFBP1 and LEP gene region may predispose to type 2 diabetes. 18828733

2009

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes. 18805913

2009

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE The female patient with type 2 diabetes became euglycemic after treatment with r-metHuLeptin and subsequent weight loss. 18854428

2009

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins. 18490929

2009

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Brain-derived neurotrophic factor (BDNF) modulates the secretion and actions of insulin, leptin, ghrelin, various neurotransmitters and peptides, and pro-inflammatory cytokines involved in energy homeostasis suggesting that it (BDNF) has a significant role in the pathobiology of obesity and type 2 diabetes mellitus. 17553627

2008

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE I propose that: (1) metabolic thrift, the capacity for efficient acquisition, storage and use of energy, is an ancient, complex trait, (2) the environmentally responsive gene network encoding this trait is subject to genetic canalization and thereby has become robust against mutational perturbations, (3) DNA sequence polymorphisms play a minor role in the aetiology of obesity and type 2 diabetes-instead, disease susceptibility is predominantly determined by epigenetic variations, (4) corresponding epigenotypes have the potential to be inherited across generations, and (5) Leptin is a candidate gene for the acquisition of a thrifty epigenotype. 18197594

2008

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Impact of genetic polymorphisms of leptin and TNF-alpha on rosiglitazone response in Chinese patients with type 2 diabetes. 18438653

2008

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. 18564365

2008

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE To investigate the association of serum levels and the -2518 A-->G promoter polymorphism of the gene for chemokine monocyte chemoattractant protein-1 (MCP-1), a major chemoattractant of monocytes and activated lymphocytes, with metabolic parameters as well as insulin, leptin and the cytokines tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in 534 Caucasian patients with type 2 diabetes mellitus. 16050950

2006

Entrez Id: 3952
Gene Symbol: LEP
LEP
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE To illustrate these concepts, we focus on epigenetic programming of insulin resistance, obesity and type 2 diabetes, with emphasis on the potential role of the adipocyte and three of its products, fatty acids, leptin and tumour necrosis factor alpha. 16778581

2006