Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
Diabetes Mellitus, Non-Insulin-Dependent
0.670 AlteredExpression BEFREE Eight weeks after liraglutide or human umbilical cord mesenchymal stem cell administration, FPG, HbA<sub>1c</sub> , glucagon, body weight, and pancreatic ASK1, JNK, and BAX mRNA and proteins were significantly decreased, and the levels of serum C-p, INS and GLP-1, ratio of insulin positive area, and Bcl-2 expression were significantly increased in three treatment groups compared with T2DM group (P<.05). 31411368

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
Diabetes Mellitus, Non-Insulin-Dependent
0.670 AlteredExpression BEFREE In addition, nesfatin-1 treatment upregulated the PCNA and Bcl2 expression and inhibited the caspase-3 and prohibitin expression in T2DM mice. 31691259

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
Diabetes Mellitus, Non-Insulin-Dependent
0.670 AlteredExpression BEFREE Western blot, ELISA and qRT-PCR results showed that the mRNA and protein expression profiles of Caspase-3 and Bax were highly up-regulated and that Bcl-2 was down-regulated in the T2DM-PD-p38 inhibitor group. 30593206

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
Diabetes Mellitus, Non-Insulin-Dependent
0.670 AlteredExpression BEFREE Furthermore, we found that the level of anti-apoptotic protein Bcl-2 was decreased (approximately 2-fold) with a concomitant increase in cleaved caspase-3 (approximately 3-fold) in T2D retina compared to control. 30453650

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
Diabetes Mellitus, Non-Insulin-Dependent
0.670 AlteredExpression BEFREE Additionally, cellular apoptosis in rats with DM was increased, and the expression of Bcl‑2 was downregulated, while levels of Bcl‑2‑associated X and caspase‑3 were upregulated, and these observations were reversed by MLT, as determined by TUNEL and western blot analysis, respectively. 29115422

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
Diabetes Mellitus, Non-Insulin-Dependent
0.670 AlteredExpression BEFREE Moreover, Ex-4 regulated several markers for autophagy in GK rat brains (as mTOR, PI3K class III, LC3 II, Atg7, p62, LAMP-1, and Parkin), ultimately protecting against apoptosis (by decreasing several caspase-like activities and mitochondrial cytochrome c, and increasing Bcl2 levels upon T2D). 28573460

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
Diabetes Mellitus, Non-Insulin-Dependent
0.670 GeneticVariation BEFREE Fourth, a multiethnic meta-analysis of all 39 studies identified T2D-associated variants in BCL2 (p = 2.1 × 10(-8)). 22325160

2012