Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 AlteredExpression BEFREE GLUT4 content and its activation as well as SLC2A4 gene expression level are decreased in patients with type 2 diabetes. 26529385

2016

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker BEFREE GLUT4 function is impaired in obesity and type 2 diabetes leading to hyperglycemia and an increased risk of cardiovascular disease and neuropathy. 25596527

2015

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker BEFREE Increased STX8 expression in VAT appears to be associated with the presence of T2D in obese patients through a mechanism that may involve GLUT4. 25523146

2015

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker BEFREE Our findings manifest that EK100 may have therapeutic potential in treating type 2 diabetes associated with hyperlipidemia in HFD-fed mice by regulation of GLUT4, PEPCK, G6 Pase, SREBP1c, SREBP2, apo A-I, and AMPK phosphorylation. 25693659

2015

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation BEFREE Recent studies in south Indian populations revealed that haplotypes of the GLUT4 gene associated with type 2 diabetes. 22673408

2013

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation BEFREE The changes in AMPK-α protein content significantly related (p < 0.001) to the changes in GLUT-4 translocation (r = 0.78) and Hb1Ac levels (r = -0.68), suggesting that AMPK signaling may be implicated in the effects of supplementation on glucose uptake in type 2 diabetes. 22349765

2013

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 AlteredExpression BEFREE H(2) significantly increased skeletal muscle membrane Glut4 expression and markedly improved glycemic control in STZ-induced type 1 diabetic mice after chronic intraperitoneal (i.p.) and oral (p.o.) administration.However, long-term p.o. administration of H(2) had least effect on the obese and non-insulin-dependent type 2 diabetes mouse models. 23326534

2013

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 AlteredExpression BEFREE Human subcutaneous adipose tissue Glut 4 mRNA expression in obesity and type 2 diabetes. 21604201

2013

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker BEFREE The determination of GLUT-4 on the surface of peripheral blood lymphocytes can be a useful tool for the evaluation of the efficacy of therapeutic actions in subjects at high risk of type 2 diabetes. 22744628

2012

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 AlteredExpression BEFREE GLUT4 protein levels may therefore play a role in the pathology behind type 2 diabetes mellitus among subgroups of patients, and this may explain the heterogeneous response to insulin treatment. 22114711

2012

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker BEFREE All our results have thus highlighted the potential of Rut as both a valuable lead compound for anti-T2DM drug discovery and a promising chemical probe for GLUT4 associated pathways exploration. 22384078

2012

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 AlteredExpression BEFREE Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes. 22340256

2012

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker BEFREE Moreover, GLUT4, a member of the solute carrier family 2, may play a role in the patient's type 2 diabetes. 22365944

2012

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation BEFREE GLUT4 gene polymorphisms and their association with type 2 diabetes in south Indians. 21668369

2012

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker BEFREE Insulin-stimulated glucose uptake by the glucose transporter GLUT4 plays a central role in whole-body glucose homeostasis, dysregulation of which leads to type 2 diabetes. 22473005

2012

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation BEFREE Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population. 20625434

2010

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation BEFREE The goal of the present study is to develop a cell-based assay for identifying negative regulators of GLUT4 translocation as potential targets for the treatment of Type 2 diabetes. 19035854

2009

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 AlteredExpression BEFREE Adaptation to states of enhanced metabolic demand is associated with increased glucose metabolism and GLUT4 gene expression, whereas states of insulin resistance such as type 2 diabetes mellitus (DM2), obesity, and aging are associated with impaired regulation of GLUT4 gene expression and function. 18492767

2008

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 AlteredExpression BEFREE Type 2 diabetes mellitus and obesity are associated with impaired regulation of GLUT4 gene expression and elevated levels of free fatty acids and proinflammatory factors. 17317207

2007

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker BEFREE In conclusion, the uncoupling of insulin action on Akt/AS160 signaling and glucose transport implicates defective GLUT4 trafficking as an early event in the pathogenesis of type 2 diabetes. 16644684

2006

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 AlteredExpression BEFREE Compared with control patients, GLUT4 protein levels were 30% lower in human cardiac muscle biopsies from patients with HL and/or type 2 diabetes mellitus, whereas GLUT4 mRNA levels were unchanged. 16096283

2005

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker BEFREE The human insulin-responsive glucose transporter 4 gene (GLUT4) has been related to non-insulin-dependent diabetes mellitus (NIDDM) in several studies. 12079888

2002

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation BEFREE Insulin-stimulated GLUT4 translocation is impaired in people with type 2 diabetes. 11334434

2001

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation BEFREE The nucleotide sequence of Glut4, a candidate gene for Nidd1nsy (a susceptibility gene for Type II diabetes) on Chromosome 11, encoding insulin-sensitive glucose transporter, was determined in NSY and C3H mice. 10952468

2000

Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation BEFREE Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations. 8904924

1997