Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE The expression of cathepsin B and X was detected in stromal cells and cancer cells throughout the GBM sections, whereas cathepsin K expression was more restricted to arteriole-rich regions in the GBM sections. 30046941

2018

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Here, we investigated the radioresistant role of Cathepsin B (CTSB), one important member of cysteine proteases, in GBM cell lines. 30099343

2018

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Tumor infiltration with activated cytotoxic T cells, induction of cathepsin B and inducible nitric oxide (NO) synthase (iNOS) expression in tumor-associated microglia/macrophages (TAM), and accumulation of activated TAM in cluster of differentiation (CD) 40 ligand (CD40L)-positive glioblastoma regions was detected. 29244745

2017

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Moreover, ATO significantly increased adhesion of U87MG cells and also diminished transcription of NF-κB down-stream targets involved in cell migration and invasion, including cathepsin B, uPA, MMP-2, MMP-9 and MMP-14 and suppressed proteolytic activity of cathepsin B, MMP-2 and MMP-9, demonstrating a possible mechanism of ATO effect on a well-known signaling in glioblastoma dissemination. 27039805

2016

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway. 27260469

2016

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. 15122332

2004

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Using mutagenesis, transient transfection and electrophoretic mobility shift assays (EMSAs), we further identified regulatory factors that mediate cathepsin B transcription in U87 human glioblastoma cells. 14669984

2004

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Furthermore, a marked reduction in microvasculature development was seen in an in vivo dorsal air sac assay of glioblastoma cells with downregulated cathepsin B expression. 14730346

2004

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells. 11439329

2001

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Using RT-PCR (reverse transcription-polymerase chain reaction) and primer extension assays, CTSB mRNA species were found to differ among tissues and between a glioblastoma sample and a cell line derived from it. 7622042

1995