Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE EGFR-amplified GBMs displayed both a higher number of concrete CNAs and a higher global tumor mutational burden than their no EGFR-amplified counterparts. 31751860

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 AlteredExpression BEFREE Here, we quantify baseline expression of MGMT and EGFR protein in newly diagnosed GBM samples using mass spectrometry. 31823165

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE U87 human GBM cells were treated with the IC50 concentration of various agents used in the treatment of GBM, including alkylating agents (temozolomide, carmustine, lomustine, procarbazine), inhibitor of topoisomerase I (irinotecan), vascular endothelial and epidermal growth factor receptor inhibitors (cediranib and erlotinib, respectively) anti-metabolite (5-fluorouracil), microtubule inhibitor (vincristine), and metabolic agents (dichloroacetate and IDH1 inhibitor ivosidenib). 30989436

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 AlteredExpression BEFREE We sought to characterize mRNA and protein content of EV subpopulations released by human glioblastoma (GBM) cells expressing a mutant form of epidermal growth factor receptor (U87<sup>EGFRvIII</sup>) <i>in vitro</i> and <i>in vivo</i> with respect to size, morphology and the presence of tumour cargo. 31839905

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE We are conducting several global studies that require central testing for EGFR amplification during screening, representing an opportunity to confirm the frequency of amplification in GBM in a large cohort and to evaluate whether EGFR amplification differs by region of the world. 31273577

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE EGFR was significantly associated with all glioma and glioblastoma in males only and a female-specific association in TERT, all of which remained nominally significant after conditioning on known risk loci. 30124908

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE Consistent with previous reports, this method detected EGFRvIII exclusively in EGFR-amplified glioblastomas [8 (44%)], which was confirmed using long-range PCR. 31000415

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE This study combines radiation therapy to prime the tumor for nanoparticle uptake along with the targeting effect of iRGD-conjugated nanoparticles to yield a straightforward but effective approach for combined EGFR inhibition and immunotherapy against glioblastomas, which can be extended to other aggressive tumor types. 30916923

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE We suppose that performing a standard molecular analysis (IDH, EGFR, p53 and Ki67) is not sufficient to predict the behavior of a GBM in regards to overall survival (OS), nor to provide a deeper understanding of the meaning of the different genetic alterations in the DNA of cancer cells. 31801254

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE We demonstrate our method using multimodal high-spectral resolution matrix-assisted laser desorption ionization (MALDI) 9.4 T MSI and 7 T in vivo MRI data, acquired from a patient-derived, xenograft mouse brain model of glioblastoma following administration of the EGFR inhibitor drug of Erlotinib. 30932478

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE Moreover, we found two genetic/clinical correlations that must be evaluated to understand their impact in the clinical setting: i) how is PTEN deletion a favorable prognostic factor in GBM IDH wildtype and an unfavorable prognostic factor in astrocytoma IDH wildtype and ii) how EGFR amplification is an independent and strong factor of response to radiotherapy. 31623593

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE EGFR gene amplification and classical subtype by TCGA analysis are associated with significantly shorter time to progression for patients with recurrent GBM when treated with bevacizumab. 30680510

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE Hence, we analyzed transcriptome data from glioblastoma cell line SF767 to predict target genes regulated by EGFR isoforms II-IV, but not by EGFR isoform I nor other receptors such as HER2, HER3, or HER4. 31438847

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE Importantly, AZD9291 inhibited GBM cell proliferation > 10 times more efficiently than the first-generation EGFR inhibitors. 31122294

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 GeneticVariation BEFREE We aimed to explore the prognostic impact of epidermal growth factor receptor copy number gain (EGFR CN gain), one of the most common genetic alterations in IDH-WT glioma, in young adults with IDH-WT GBM. 31542863

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE MTT method was used to test the cell viability after EGFR-positive glioblastoma cells were treated with indicated drugs; real-time quantitative PCR method was included to detect the TNFα mRNA levels in glioma tissues and cell lines. 31565489

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE <b>Methods</b>: Newly diagnosed patients with histologically proven single supratentorial GBM and epidermal growth factor receptor (EGFR) positive expressions were recruited. 31289592

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE Noncanonical genes in GB could be a key for future therapeutic strategies targeting EGFR-dependent gliomas. 30506943

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE They find that ELOVL2 products help maintain cell membrane organization and EGFR signaling in GSCs, and that targeting PUFA metabolism along with EGFR offers a potential novel therapeutic strategy for glioblastoma.<i>See related article by Gimple et al., p. 1248</i>. 31481405

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE We aimed to investigate EGFR/DNA combi-targeting in GBM. 31540977

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE Precision medicine trials targeting the epidermal growth factor receptor (EGFR) in glioblastoma patients require selection for EGFR-amplified tumors. 31125418

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE Here, we identified two enhancers (CE1 and CE2) present within the first intron of the <i>EGFR</i> gene in models of glioblastoma (GBM) and head and neck squamous cell carcinoma (HNSCC). 31444232

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE Our data identify ALDH levels as a biomarker of GBM cells with high invasive potential, altered oxidative stress, and resistance to EGFR inhibition, and reveal a therapeutic target whose inhibition should limit GBM invasion. 31270152

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE Here we report efficacy, safety and pharmacokinetics (PK) of depatux-m + temozolomide (TMZ) in patients with EGFR-amplified rGBM. 29982805

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 Biomarker BEFREE Chen and colleagues leverage a <i>Drosophila</i> GBM model to identify a conserved signaling axis downstream of the EGFR and PI3K that involves the death-associated protein kinase (Drak), a cytoplasmic serine/threonine kinase orthologous to the human kinase STK17A. 30877099

2019