Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker BEFREE We review the current state of diagnostic molecular markers for gliomas, focusing on isocitrate dehydrogenase 1 or 2 (IDH1/IDH2) gene mutation, α-thalassemia/mental retardation syndrome X-linked (ATRX) gene mutation, 1p/19q co-deletion and telomerase reverse transcriptase (TERT) promoter mutation in adult tumors, as well as v-raf murine sarcoma viral oncogene homolog B1 (BRAF) and H3 histone family 3A (H3F3A) aberrations in pediatric gliomas. 26948350

2016

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation BEFREE Detecting the H3F3A mutant allele found in high-grade pediatric glioma by real-time PCR. 26376656

2016

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation BEFREE CDKN2A, and PTEN in high-grade gliomas, followed by BRAF fusions in low-grade gliomas and H3F3A mutations in pediatric gliomas. 26681766

2016

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation BEFREE Pediatric gliomas differ in their spectrum of disease from those in adults; high grade gliomas occurring in children frequently have mutations in H3F3A, ATRX and DAXX, but not IDH. 26004297

2016

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation BEFREE We performed gene mutation analysis of IDH1 and H3 histone family 3A (H3F3A), status evaluation of glioma cytosine-phosphate-guanine island methylator phenotype (G-CIMP), and Gene Ontology analysis. 24997139

2015

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation BEFREE Mutations in histone genes H3F3A (encoding H3.3) and HIST1H3B (encoding H3.1) were found in 3/8 (37.5 %) of the DIBG (two H3F3A (K27M) and one HIST1H3B (K27M) ) versus 6/205 (2.9 %) of the supratentorial high-grade gliomas (four H3F3A (G34R) and two H3F3A (K27M) ) (p = 0.002). 24242757

2014

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker BEFREE Prevalences of mutations of isocitrate dehydrogenase 1 (IDH1) and histone H3.3 (H3F3A), the glioma cytosine-phosphate-guanine island methylator phenotype (G-CIMP), and methylation of alkylpurine DNA N-glycosylase (APNG) and peroxiredoxin 1 (PRDX1) promoters were determined in a representative biomarker subset (n = 126 patients with anaplastic astrocytoma or glioblastoma) from the NOA-08 trial. 23595628

2014

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation BEFREE H3F3A K27M mutations in thalamic gliomas from young adult patients. 24285547

2014

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation BEFREE Sequencing of pediatric gliomas has identified missense mutations Lys27Met (K27M) and Gly34Arg/Val (G34R/V) in genes encoding histone H3.3 (H3F3A) and H3.1 (HIST3H1B). 23539183

2013

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation BEFREE Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of high-grade pediatric glioma cases. 23603901

2013

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation BEFREE H3F3A mutations were specific to pediatric high-grade gliomas and identified in only 3.4 % of adult GBM. 22886134

2013

Entrez Id: 3020
Gene Symbol: H3F3A
H3F3A
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation BEFREE Screening of a large cohort of gliomas of various grades and histologies (n = 784) showed H3F3A mutations to be specific to GBM and highly prevalent in children and young adults. 22286061

2012