Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4763
Gene Symbol: NF1
NF1
CUI: C0017638
Disease: Glioma
Glioma
0.580 GeneticVariation BEFREE Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness. 30967630

2019

Entrez Id: 4763
Gene Symbol: NF1
NF1
CUI: C0017638
Disease: Glioma
Glioma
0.580 Biomarker BEFREE Furthermore, NF1 loss was associated with worse overall and disease-specific survival in the lower-grade glioma, but not GBM, Group in The Cancer Genome Atlas cohort. 26190195

2015

Entrez Id: 4763
Gene Symbol: NF1
NF1
CUI: C0017638
Disease: Glioma
Glioma
0.580 GeneticVariation BEFREE In this regard, mutational inactivation of neurofibromatosis-1 (NF1), tuberous sclerosis complex (TSC), and PTEN genes is associated with glioma formation, such that pharmacologic inhibition of mTOR signaling results in attenuated tumor growth. 21896734

2011

Entrez Id: 4763
Gene Symbol: NF1
NF1
CUI: C0017638
Disease: Glioma
Glioma
0.580 Biomarker BEFREE In this review, we highlight advances in neurofibromatosis type 1 (NF1) genetically engineered mouse brain tumor (glioma) modeling to reveal how cellular and molecular heterogeneity in both the pre-neoplastic/neoplastic and non-neoplastic cellular compartments contribute to gliomagenesis and glioma growth. 21076468

2011

Entrez Id: 4763
Gene Symbol: NF1
NF1
CUI: C0017638
Disease: Glioma
Glioma
0.580 Biomarker BEFREE Previous studies from our laboratories have used neurofibromatosis-1 (NF1) genetically engineered mouse (GEM) models to understand the spatial restriction of glioma formation to the optic pathway of young children. 20551058

2010

Entrez Id: 4763
Gene Symbol: NF1
NF1
CUI: C0017638
Disease: Glioma
Glioma
0.580 Biomarker BEFREE We and others have previously shown that brain tumor (glioma) formation in Nf1 genetically engineered mice requires a microenvironment composed of cells heterozygous for a targeted Nf1 mutation. 17400655

2007

Entrez Id: 4763
Gene Symbol: NF1
NF1
CUI: C0017638
Disease: Glioma
Glioma
0.580 GeneticVariation BEFREE Somatic mutations in the neurofibromatosis 1 gene in gliomas and primitive neuroectodermal tumours. 8669813

1996

Entrez Id: 4763
Gene Symbol: NF1
NF1
CUI: C0017638
Disease: Glioma
Glioma
0.580 GeneticVariation BEFREE No germline mutations were found, suggesting that the genetic basis of familial glioma is distinct from that of gliomas occurring in the Li-Fraumeni syndrome, and that inherited mutations of the catalytic domain of neurofibromin do not predispose affected glioma families to these tumors. 8285583

1994