Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 Biomarker BEFREE Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma. 26839018

2017

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE The role of the RTEL1 rs2297440 polymorphism in the risk of glioma development: a meta-analysis. 26939676

2017

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE We confirmed the association with glioma risk for variants within five genomic regions: 8q24.21 (CCDC26), 9p21.3 (CDKN2B-AS1), 11q23.3 (PHLDB1), 17p13.1 (TP53), and 20q13.33 (RTEL1). 25713050

2016

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE The past few years have witnessed the emergence of RTEL1 variants that confer increased susceptibility to high-grade glioma, astrocytomas, and glioblastomas. 24582487

2015

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Genome-wide association studies have implicated single nucleotide polymorphisms (SNPs) in 7 genes as glioma risk factors, including 2 (TERT, RTEL1) involved in telomerase structure/function. 23733245

2014

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Regulator of telomere elongation helicase 1 (RTEL1) rs6010620 polymorphism contribute to increased risk of glioma. 24523019

2014

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Genetic variants in or near RTEL1 and TERT, key components of telomere biology, are associated with glioma risk. 24231251

2014

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE In conclusion, as previously shown for glioma regardless of family history of brain tumours, rs6010620 (RTEL1) was associated with an increased risk of glioma when restricting to cases with family history of brain tumours. 23115063

2013

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1). 23161787

2013

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 Biomarker BEFREE Eight SNPs in/near seven different genes (TERT, EGFR, CCDC26, CDKN2A, PHLDB1, RTEL1, TP53) were significantly associated with glioma risk in the combined dataset (P < 0.05), with all associations in the same direction as in previous reports. 23280628

2013

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE RTEL1 tagging SNPs and haplotypes were associated with glioma development. 23683922

2013

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Among 99 SNPs, five independent susceptibility loci (20-62315594 in RTEL1, 20-62335293 in adenosine diphosphate ribosylation factor-related protein 1, rs3761121 in ZGPAT, rs1058319 in SLC2A4RG and rs5019252 in ZBTB46) were identified for glioma. 22387365

2012

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)). 21350045

2011

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Three of the gene variants (rs4295627, a variant of CCDC26; rs4977756, a variant of CDKN2A and CDKN2B; and rs6010620, a variant of RTEL1) were statistically significantly associated with glioma risk in the present population. 21920947

2011

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR). 21825990

2011

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). 21742680

2011

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Two recent genome-wide association studies reported that single nucleotide polymorphisms (SNPs) in (or near) TERT (5p15), CCDC26 (8q24), CDKN2A/B (9p21), PHLDB1 (11q23), and RTEL1 (20q13) are associated with infiltrating glioma. 21356187

2011

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk. 20847058

2011

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk. 20462933

2010

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. 19578366

2009

Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
CUI: C0017638
Disease: Glioma
Glioma
0.500 GeneticVariation BEFREE We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367

2009