Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Therapeutic targeting of USP9X led to preferential inhibition of the ERG-dependent leukemias. 31175119

2019

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE ERG-related leukemia is a B cell precursor acute lymphoblastic leukemia (BCP ALL) subtype characterized by aberrant expression of DUX4 and ERG transcription factors, and highly recurrent ERG intragenic deletions. 28415578

2017

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation BEFREE These results illustrate a unique paradigm of transcription factor deregulation in leukemia in which DUX4 deregulation results in loss of function of ERG, either by deletion or induced expression of an isoform that is a dominant-negative inhibitor of wild-type ERG function. 27776115

2016

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE In conclusion, our data suggest that neither the expression of aberrant proteins from internally deleted allele nor the reduced expression of wild type ERG seem to provide a plausible explanation of the specific biology of ERG -related leukemia subgroup. 27494621

2016

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression BEFREE These results support a model whereby a stem cell gene expression network driven by high ERG in human cells enhances the expansion of the progenitor pool, providing opportunity for the acquisition and propagation of mutations and the development of leukemia. 25306899

2015

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression BEFREE We hypothesize that ERG overexpression is associated with primary drug resistance thereby influencing the outcome in leukemia. 24504051

2014

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Thus, integrative genomic analysis demonstrates that ERG causes myeloid progenitor leukemia characterized by an induction of leukemia stem cell transcriptional programs. 23974202

2013

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression BEFREE We investigated the regulation of ERG by microRNAs and explored their role in hematopoiesis and leukemia. 20570349

2011

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. 21519790

2011

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Using this array, proof of principle was demonstrated by detection of known fusion genes (such as TCF3:PBX1, ETV6:RUNX1, and TMPRSS2:ERG) from all six positive controls consisting of leukemia cell lines and prostate cancer biopsies. 19152679

2009

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE The proto-oncogene ERG in megakaryoblastic leukemias. 16140924

2005

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias. 9178886

1997

Entrez Id: 2078
Gene Symbol: ERG
ERG
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Thus, the TLS/FUS-ERG gene fusion in t(16;21) leukemia is predicted to produce a protein that is very similar to the EWS-ERG chimeric protein responsible for Ewing's sarcoma. 8187069

1994