Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3981
Gene Symbol: LIG4
LIG4
CUI: C0023418
Disease: leukemia
leukemia
0.340 AlteredExpression BEFREE Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA ligase IV transcription of daunorubicin-resistant leukemia cell lines. 24530422

2014

Entrez Id: 3981
Gene Symbol: LIG4
LIG4
CUI: C0023418
Disease: leukemia
leukemia
0.340 GeneticVariation BEFREE Mutations of Lig4 are exclusively hypomorphic and have only been described in six patients, four exhibiting mild immunodeficiency associated with microcephaly and developmental delay, while two patient had leukemia. 16358361

2006

Entrez Id: 3981
Gene Symbol: LIG4
LIG4
CUI: C0023418
Disease: leukemia
leukemia
0.340 GeneticVariation BEFREE We investigated the potential impact that previously undescribed polymorphisms identified within NHEJ DNA ligase IV (LIG4) have upon predisposition to several lymphoproliferative disorders, including leukaemia, lymphoma, and multiple myeloma. 12471202

2002

Entrez Id: 3981
Gene Symbol: LIG4
LIG4
CUI: C0023418
Disease: leukemia
leukemia
0.340 Biomarker BEFREE Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. 10395545

1999