Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE In addition, this inhibitor may serve as a promising therapeutic strategy for MLL leukemia by targeting CBP BrD protein. 31253937

2020

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE There is a high unmet need to identify safer and more potent therapies for MLL-rearranged (MLL-r) leukemia that can be combined with established chemotherapeutics to decrease treatment-related toxicities. 31325323

2020

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Here, we studied the distribution and characteristics of Tregs in the LHME, investigated the effects of Treg ablation on leukemia progression, explored the mechanisms leading to Treg accumulation, and studied whether blocking Treg migration to the LHME delayed leukemia progression in MLL-AF9-induced mouse acute myeloid leukemia (AML) models using wildtype (WT) and Foxp3<sup>DTR/GFP</sup> mice. 31669202

2020

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Dysregulation of MLL1 catalytic function is relevant to mixed-lineage leukemia, and targeting WDR5-MLL1 interaction could be a promising therapeutic strategy for leukemia harboring MLL1 fusion proteins. 30626558

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia. 31545325

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation BEFREE From our data we conclude that the scaffold protein 14-3-3θ enhances the aberrant activity of the chimeric transcription factor MLL-AF4 and, therefore, represents a new player in the molecular pathogenesis of t(4;11)-positive leukemia and a new promising therapeutic target. 31493143

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation BEFREE We found that SOCS5 was differentially expressed in primary T-ALL and its expression levels were lowered in HOXA-deregulated leukemia harboring KMT2A gene rearrangements. 30974024

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE In this review, we will discuss the role of MLL and its fusion partners in normal HSPCs and hematopoiesis, including the links between chromatin effectors, epigenetic landscapes, and leukemia development, and summarize current approaches to therapeutic targeting of <i>MLL</i>-r leukemias. 31157223

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Our findings demonstrate that the abnormal elevated expression of circAF4 regulates the cell growth via the circAF4/miR-128-3p/MLL-AF4 axis, which could contribute to leukemogenesis, suggesting that circAF4 may be a novel therapeutic target of MLL-AF4 leukemia. 31623653

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Most importantly, IDA/MPEG-PLGA NPs significantly decreased the infiltration of leukemia blasts and improved the overall survival of MLL-AF9-induced murine leukemia compared with free IDA. 30666113

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Therefore, a new acute monocytic leukemia cell line with clear biological and molecular features was established and may be used in the research and development of new agents targeting KMT2A-associated leukemia. 31701557

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE The efficiency of murine MLL-ENL-driven leukemia initiation changes with age and peaks during neonatal development. 31405949

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation BEFREE SETD2, an epigenetic tumor suppressor, is frequently mutated in MLL-rearranged (MLLr) leukemia and relapsed acute leukemia (AL). 30967619

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Here we address the role of MLL-FPs in the initiation of leukemia in the absence of endogenous MLL1. 31161857

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE <i>LAMP5</i> was validated as being specifically and highly expressed in patients with MLL leukemia and was associated with a poor outcome. 30651276

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE The developmental stage of the hematopoietic niche regulates lineage in <i>MLL-</i>rearranged leukemia. 30728174

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE This study provides insights into the direct regulation of the stability of MLL1 through its cleavage by taspase1, which can be harnessed for targeted therapeutic approaches for the treatment of aggressive leukemia as the result of MLL translocations. 30573454

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Furthermore, auranofin delayed the progression of leukemia in MLL-rearranged patient-derived xenograft model and prolonged the survival of leukemic NSG mice. 30861284

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE The MLL1-AF10 fusion causes leukemia through recruiting the H3K79 histone methyltransferase DOT1L via AF10's octapeptide and leucine zipper (OM-LZ) motifs. 31527241

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE In summary, our findings demonstrate that MN1 plays an essential role in MLL fusion leukemias and serve as a therapeutic target in MLL-rearranged acute myeloid leukemia. 31413090

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE DOT1L methylates histone H3K79 and is aberrantly regulated in MLL-rearranged leukemia. 31304633

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation BEFREE JMJD1C, a member of the lysine demethylase 3 family, is aberrantly expressed in mixed lineage leukemia (MLL) gene-rearranged (MLLr) leukemias. 31076406

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex. 30679799

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Patient-derived xenograft (PDX) models derived from patients with either MLL-r acute myeloid leukemia or MLL-r acute lymphoblastic leukemia (ALL) showed dramatic reductions of leukemia burden when treated with VTP50469. 31821784

2019

Entrez Id: 4297
Gene Symbol: KMT2A
KMT2A
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Moreover, development of additional methods to detect specific translocation partners of KMT2A and leukemia-specific targeting drugs is important to improve further the outcomes of KMT2A-rearranged AML. 30869817

2019