Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE TRAIL is currently under investigation for the treatment of leukemia. 30257312

2018

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression BEFREE Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) down-regulation by preferentially expressed antigen of melanoma (PRAME) is a general phenomenon in different types of solid tumours, but research on the correlation between PRAME and TRAIL gene expression in leukaemia patients is rare. 24008770

2013

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression BEFREE BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia. 22665066

2013

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE It enhanced cytotoxicity in TRAIL-treated K562 leukemia cells and reduced TRAIL-induced apoptosis in HCT116 and SW480 colon cancer cells, while having no effect on PC3 and LNCaP cells. 22462553

2012

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Here we investigated whether TRAIL targets leukemia-initiating cells. 22408264

2012

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE Overall, HDACi represent a promising and safe strategy in combination with TRAIL for treatment of T-cell leukaemia. 20580868

2010

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression BEFREE Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: in vitro and in vivo evaluation. 19417152

2009

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0023418
Disease: leukemia
leukemia
0.400 AlteredExpression BEFREE Expression of the TRAIL receptors in blood mononuclear cells in leukemia. 18158563

2007

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation BEFREE In summary, constitutive TRAIL susceptibility differs between leukemia subtypes and does not correlate with mRNA expression levels of the TRAIL receptors R1-R4 as well as constitutive NF-kappa B activation status. 11417478

2001

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0023418
Disease: leukemia
leukemia
0.400 Biomarker BEFREE These data suggest that TRAIL might participate in CD95-independent apoptosis of lymphoid cells and might be involved in deregulated apoptosis in diseases such as leukemias and HIV-1 infection. 9485194

1998