Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 AlteredExpression BEFREE Furthermore, knockdown of LINC00982 expression by small interfering RNA (siRNA) could promote cell proliferation and cell cycle progression, while ectopic expression of LINC00982 inhibited cell proliferation and rendered cell cycle arrest in GC cells partly via regulating P15 and P16 protein expressions. 26334618

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE ANRIL, a lncRNA co-clustered mainly with p14/ARF has been reported to be dysregulated in gastric cancer, esophageal squamous cell carcinoma, and lung cancer. 25966845

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. 25890171

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 AlteredExpression BEFREE These data unravel a crucial role of EZH2 in the regulation of INK4/ARF expression and senescence procedure in gastric cancer cells, and show that the cellular senescence could just depend on the activation of p15(INK4b)/Rb pathway, suggesting the cell-type and species specificity involved in the mechanisms of senescence inducement. 26004298

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 AlteredExpression BEFREE Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer. 23175521

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE We demonstrated that MKRN1 functions as a novel E3 ligase of p14ARF and that it potentially regulates cellular senescence and tumorigenesis in gastric cancer. 23104211

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE On the other hand, the observed pattern of p16 (INK4A) hypermethylation suggests that this event is a good marker for the gastric cancer pathway in the Pará state population. 23504555

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 AlteredExpression BEFREE Our results demonstrate that STAT3, but not STAT5, is involved in GC cell growth and cell cycle progression through regulation of gene expression, such as Bcl-2, p16(ink4a) and p21(waf1/cip1). 22328012

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 GeneticVariation BEFREE To explore germline hypermethylation of the tumor suppressor genes MLH1, CDH1 and P16(INK4a) in suspected cases of hereditary gastric cancer (GC). 22228973

2012

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE Evaluating LINE-1, TP53 and p16 jointly yielded a more pronounced negative association with gastric cancer (OR: 0.24; 95% CI: 0.09-0.66).Age was a significant effect modifier. 22126203

2012

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer. 20637757

2011

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE Lastly, a CCND1/CDKN2A assay with clinical samples showed that uterine cervical and small cell lung cancers known to have a high prevalence of RB1-decifiency were predicted to be 100% RB1-negative, while uterine endometrial or gastric cancers were predicted to be 5-22% negative. 21447152

2011

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 AlteredExpression BEFREE Downregulation of BMI1 by Mel-18 overexpression or knockdown of BMI1 expression in gastric cancer cell lines led to upregulation of p16 (p16INK4a or CDKN2A) in p16 positive cell lines and reduction of phospho-AKT in both p16-positive and p16-negative cell lines. 20170541

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 AlteredExpression BEFREE Knockdown of CBX7 expression in gastric cancer cells led to increased cellular senescence, decreased cellular proliferation and migration ability, accompanied by upregulation of p16(INK4a). 20723236

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE To investigate the relationship between p16 methylation and Helicobacter pylori infection in precancerous gastric lesions, a population-based study was conducted in Linqu County, a high-risk area of gastric cancer in China. 18821580

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE E2F promoter-regulated oncolytic adenovirus with p16 gene induces cell apoptosis and exerts antitumor effect on gastric cancer. 19034663

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 AlteredExpression BEFREE CIHM rates of DAPK, Ecad, and p16 promoters were significantly higher in noncancerous gastric mucosa of gastric cancer patients (91, 88, and 68%, respectively) than in noncancerous controls (71, 53, and 25%, respectively). 18205664

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE We used chromatin immunoprecipitation (ChIP) assay to assess the status of histone acetylation and methylation in promoter regions of the p16 and mutL homolog 1 (MLH1) genes in 2 gastric cancer cell lines, SGC-7901 and MGC-803. 18069755

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE No precursor lesions were available from the gastric cancers that had loss of both MTAP and p16. 16224217

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 PosttranslationalModification BEFREE Detection of p16 promoter hypermethylation in serum of gastric cancer patients. 12824886

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 AlteredExpression BEFREE The frequency of loss of P16 protein expression in the gastric cancer tissue, adjacent nontumor tissue, and distal normal tissue was 77.5 % (31/40), 55.0 % (22/40), and 17.5 % (7/40), respectively (P<0.005). 12717828

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 AlteredExpression BEFREE Studies on microsatellite instability in p16 gene and expression of hMSH2 mRNA in human gastric cancer tissues. 12632492

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 Biomarker BEFREE To investigate the expression of human telomerase reverse transcriptase gene (hTRT) in gastric cancer (GC) and its relevance with cell cycle regulators including P16INK4, cyclin and P53. 12632490

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 GeneticVariation BEFREE Methylation and mutation analysis of p16 gene in gastric cancer. 12632489

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.600 GeneticVariation BEFREE Expression, deletion [was deleton] and mutation of p16 gene in human gastric cancer. 11819820

2002