Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE Taken together, our data suggested that EGCG inhibits GC growth and reverses 5-FU resistance of GC through inactivation of TFAP2A/VEGF pathway and down-regulation of MDR-1 and P-gp expression. 29137307

2017

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE More significantly, the strong correlation of DCTPP1 and MDR1 expression was detectable in clinical GC samples. 27612427

2016

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Thus, we found that HIF-1α is closely associated with MDR in GC and that HIF-1α may suppress MDR1/P-gp, LRP and Bcl-2 expression by inhibiting miR-27a expression. 26292288

2015

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE These preliminary results indicate that the c.3073A>C genetic polymorphism of the MDR1 gene is potentially related to the susceptibility to gastric cancer in the Chinese Han population. 24116826

2014

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE MTT assay, RT-PCR, Western blotting were employed to detect susceptibility of GC cells to chemotherapeutic agents (5-FU, L-OHP) in vitro, and expressions of ZNF139 and MDR associated genes MDR1/P-gp, MRP1, Bcl-2, Bax were also detected. siRNA specific to ZNF139 was transfected into MKN28 cells, then chemosensitivity of GC cells as well as changes of ZNF139 and MDR associated genes were detected. 24515389

2014

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE This meta-analysis suggested that the MDR1 C3435T polymorphism is not associated with susceptibility to GC and PU. 24815441

2014

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE This study aimed to analyze the association between genetic variants of MDR1 gene and the susceptibility to gastric cancer in Chinese Han population. 23801278

2013

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE Multiple drug resistance 1/P-glycoprotein (MDR1/p-gp) contributes to drug resistance via ATP-dependent drug efflux pumps and is overexpressed in many solid tumors including gastric cancer. 24377601

2013

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE No correlation was observed between the C3435T polymorphism of the MDR1 gene and GC risk or prognosis in the population studied. 22641402

2012

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Methylation status of MDR1 gene in noncancerous gastric mucosa would be useful for predicting GC occurrence. 20636108

2010

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 PosttranslationalModification BEFREE The methylation of the MDR1 promoter was estimated in both antral non-neoplastic mucosa and cancer lesions in 83 patients with gastric cancer using a methylation-specific PCR method. 19331170

2009

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE In this preliminary data, the association with MDR1 C3435T polymorphism and risk for developing H. pylori-related gastric cancer and peptic ulcer in Japanese was low. 18644389

2008

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE We investigated the influences of MDR1 gene polymorphism on the risk of gastric cancer. 17608636

2007

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 PosttranslationalModification BEFREE Luciferase reporter assay suggested that Runx3 inhibited the promoter activity of the MDR-1 and MRP-1 promoter in SGC7901 cells. 15756676

2005

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE To detect the expression of glutathione S-transferase Pi(GST-pi), multidrug resistance-associated protein (MRP), lung-resistance protein(LRP), multidrug resistance gene1 (MDR1) and MGr1 antigen(MGr1-Ag) in the patients with primary gastric cancer and without any prior chemotherapy and to evaluate the correlations between them. 11205224

2001

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE We conclude that the expression of MDR-1 in gastric cancer is high in Turkey, and this may be related to poor prognosis. 10446694

1999

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE Fresh surgical specimens of 52 gastric cancers and 25 colorectal cancers were analyzed for the expression of multidrug resistance (mdr-1) gene mRNA with non-isotopic in situ hybridization (ISH) using a biotin-labeled oligonucleotide probe. 9677442

1998

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE We specifically examine the magnitude and the biologic significance of multidrug resistance-1 (MDR-1) expression in human gastric cancer. 9649010

1998

Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE Northern blot analysis by pmdr1 probe showed that stomach cancer cell lines had no detectable level of MDR1 mRNA expression. 1735085

1992