Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE This study elucidated whether Helicobacter pylori-infected first-degree relatives of patients with gastric cancer (GCF) are susceptible to have SPEM and correlated with miR-21, 155, and 223 expressions. 30990573

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE Ex-miR-21 levels were significantly higher and ex-miR-92a levels were significantly lower in samples from patients with GC compared with healthy controls. 31611956

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Evaluation of circulating miR-21 and miR-222 as diagnostic biomarkers for gastric cancer. 30880765

2019

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Overexpressed miR-21 was observed in GC tissues and cell lines. 29710493

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE miR-21 Inhibitors Modulate Biological Functions of Gastric Cancer Cells via PTEN/PI3K/mTOR Pathway. 29185784

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE In the present study, we investigated the relationship between MEG3 and miR‑21 in regards to the cell mobility of gastric cancer. 29749532

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Importantly, increased miR‑21‑5p expression levels at diagnosis were correlated with clinicopathological characteristics including advanced stage and poor prognosis, further implying that a relapse of GC may be a consequence of miR‑21‑5p upregulation, thus providing evidence for the potential utility of miR‑21‑5p antagonism to sensitize GC cells to DOX chemotherapy. 29393355

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE These results indicate SMAD7 may mediate the oncogenic properties of miRNA-21-5p in gastric cancer, and miRNA-21-5p would be a promising strategy for the treatment of gastric cancer. 30147341

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE The exosomal miR-21-5p may be a novel therapeutic target for GC peritoneal metastasis. 30154401

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE In conclusion, our findings enlarged our knowledge in the roles of miR-21 in the progression of gastric cancer. 29101039

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE PDHA1 downregulation promoted gastric cancer glycolysis and cancer progression. miR‑21‑5p directly targeted PDHA1 to suppress PDHA1 expression, and promote glycolysis as well as cell proliferation in gastric cancer. 30226598

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE miRNA-21 promotes gastric cancer growth by adjusting prostaglandin E2. 29687845

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE miR-21 can be used for the diagnosis of gastric cancer and prognosis of lymph node metastasis in gastric cancer. 28121346

2017

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE This study is a continuation of earlier findings involving poly(ε-caprolactone) (PCL)-poly (ethylene glycol) (PEG) nanoparticles (PEG-PCL NPs), which were coated with trastuzumab to target GC with HER2 receptor over-expression using anti-miRNA-21 (AMO-21) and 5-Fu. 29241186

2017

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Our findings suggest that exosomal transfer of tumor-associated macrophages derived miR-21 confer DDP resistance in gastric cancer, and targeting exosome communication may be a promising new therapeutic strategy for gastric cancer patients. 28407783

2017

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE The results of the current study demonstrated that there was a higher expression of VEGF and miR-21 in GC tissues compared with that in morphologically adjacent normal tissues whereas PPARα expression was decreased. 29142602

2017

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Enhanced antiproliferative activity of antibody-functionalized polymeric nanoparticles for targeted delivery of anti-miR-21 to HER2 positive gastric cancer. 28978026

2017

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE These results implicate that urine miR-21-5p could be utilized as a novel non-invasive biomarker of gastric cancer detection and monitoring. 28915598

2017

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Overall, the proposed strategy could be satisfactory for rapid, ultrasensitive and efficient detection of microRNA-21, and held great potentials in clinic diagnosis of gastric cancer. 28919434

2017

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Bmi-1 positively regulates stem cell-like properties of gastric cancer and upregulates miR-21 and miR-34a. 27644439

2016

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE Recent evidences indicate that miR-21 is overexpressed in tumour tissue, including gastric cancer and plays a vital role in tumour cell proliferation, apoptosis, invasion and angiogenesis. 27179559

2016

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE MiR-21 inhibitors significantly inhibit cell migration and invasion in GC cell lines. 27611950

2016

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE Mel-18 negatively regulates stem cell-like properties through downregulation of miR-21 in gastric cancer. 27542229

2016

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE The present study investigated the effect of miR‑21 on the clinical features, proliferation, invasion and migration of gastric cancer and the underlying mechanisms associated with Noxa. 26847916

2016

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE MicroRNA-21: Mechanisms of Oncogenesis and its Application in Diagnosis and Prognosis of Gastric Cancer. 26265521

2015