Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Genetic variants in PI3K/Akt/mTOR pathway genes contribute to gastric cancer risk. 29802999

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer. 28550907

2017

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Ultimately, PI3K p110α represents a novel target for gastric cancer. 26543351

2016

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Recent studies on the genomic landscape of gastric adenocarcinoma have identified several key signaling molecules, including epidermal growth factor receptor family (ErbB) members, vascular endothelial growth factor receptor family (VEGFR) members and PI3K/Akt/mTOR pathway components, that have been implicated in the molecular pathogenesis of gastric cancers. 26398764

2016

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Herein, we review the common dysregulation of PI3K/Akt/mTOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. 26604635

2016

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Fra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 signaling pathway in gastric cancer. 26330014

2016

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Similar to human GC, pathway analyses identified WNT, TGF-β, and PI3K-PTEN signaling, ubiquitin-mediated proteolysis, adherens junctions, and RNA degradation in addition to genes involved in chromatin modification and organization as highly deregulated pathways in GC. 27006499

2016

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE TGF-β1-induced PI3K/Akt/NF-κB signaling pathway was involved in the pathogenesis of GC and they could be a new target for cancer therapy. 25613482

2016

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt pathway is involved in the tumor suppressor effects of BMP9 in gastric cancer. 25640278

2016

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer. 25914465

2016

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Celecoxib sensitizes gastric cancer to rapamycin via inhibition of the Cbl-b-regulated PI3K/Akt pathway. 25701378

2015

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pathway for gastric cancer metastasis. 25727320

2015

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE PIK3CA mutant (AGS, HGC27), and wild-type (MKN45, NUGC4) gastric cancer cells were cultured in high-glucose (HG, 25 mM) or low-glucose (LG, 5 mM) media and tested for sensitivity to two cytotoxic compounds, 5-fluorouracil (5-FU) and carboplatin, the PI3K/mTOR inhibitor, PI103 and the mTOR inhibitor, Ku-0063794. 24597478

2015

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Mechanically, PTP1B promotes gastric cancer cell proliferation, survival and invasiveness through modulating Src-related signaling pathways, such as Src/Ras/MAPK and Src/phosphatidylinositol-3-kinase (PI3K)/Akt pathways. 25590580

2015

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE PPP1R1B-STARD3 chimeric fusion transcript in human gastric cancer promotes tumorigenesis through activation of PI3K/AKT signaling. 24276243

2015

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE In conclusion, this CagA- PI3K/AKT-Sp1-RBP2-Cyclin D1 pathway may serve as a novel mechanism for gastric epithelial cell malignant transformation and then gastric cancer (GC). 25015565

2015

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE The signaling mechanism of NT in gastric cancer cells was confirmed in protein kinase C (PKC), extracellular-signal regulated kinase (ERK), and phosphatidylinositol 3-kinase (PI3K) pathway. 25724188

2015

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Notch2 may negatively regulate cell invasion by inhibiting the PI3K-Akt signaling pathway in gastric cancer. 23326131

2014

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Taken together, our data reveal a novel mechanism that PTEN inhibits the growth and invasion of gastric cancer via the downregulation of FAK expression and suggest that exploiting PTEN/PI3K/NF-κB/FAK axis is a promising approach to treat gastric cancer metastasis. 24486402

2014

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE The genetic variants in the PI3K/PTEN/AKT especially the GG allele in 3' side of AKT1 are closely related to clinical outcomes of gastric cancer. 24737346

2014

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression BEFREE The effects of miR-34a ectopic expression on the AKT and p-AKT expression of cisplatin-induce gastric cancer cells were determined by Western blot and flow cytometry with the PI3K pathway inhibitor Wortmannin. 24068565

2014

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells. 23376640

2013

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE The viability of gastric cancer cells was inhibited after siRNA targeting to the Class I PI3K blocked Class I PI3K signal pathway. 23555164

2013

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 PosttranslationalModification BEFREE PI3K/Akt-dependent phosphorylation of GSK3β and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration. 23123500

2013

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 Biomarker BEFREE Semaphorin 5A could promote invasion and metastasis of gastric cancer through the PI3K/Akt/uPA signal transduction pathway. 23661031

2013