Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Effect of p53β on human gastric cancer cells treated with recombinant mutated human TNF and cisplatin. 28393225

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE High expression of tumor necrosis factor receptor-associated factor 2 promotes tumor metastasis and is associated with unfavorable prognosis in gastric cancer. 28482378

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Interestingly, low concentrations of edelfosine (5-10 μM) effectively enhanced recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (rhTRAIL/TNFSF10)-induced apoptosis and clonogenicity in gastric cancer cells, including TRAIL-resistant AGS cells. 26615420

2017

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Tumor necrosis factor receptor-associated factor 1 (TRAF1) is a member of the TRAF family and is dysregulated in diseases, such as atheroma, lymphoma, and solid tumors, but the role of TRAF1 in gastric cancer remains unknown. 27060717

2017

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Effect of expressions of tumor necrosis factor α and interleukin 1B on peritoneal metastasis of gastric cancer. 26069103

2016

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE These results suggest that the TNF-α(-193) (G/A) allele has a protective function against gastric cancer by developing ulcer. 26504356

2016

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: a systematic review and meta-analysis. 25125137

2016

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Taken together, our findings provide evidence for an association of TNF-α-857 C/T, IL-8-845 T/C, and IL-10-592 C/A with a higher risk of gastric cancer and also demonstrate the influence that the polymorphic C allele of IL-8-845 has on changes to the gene expression levels of this cytokine. 26088449

2016

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are correlated with gastric cancer in central China. 24277417

2015

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Purification of a Pd20-TNFα fusion protein that prevents liver metastasis of gastric cancer. 24789430

2015

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells. 25548484

2015

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Large meta-analyses confirmed the association between IL8, IL10, TNF-b, TP53 and PSCA, while genetic variation at different genes such as XPG, PLCE1, HFE, ERCC5, EZH2, DOC2, CYP19A1, ALDH2, and CDH1 have been reported to be associated with GC risk. 24011243

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric cancer: a meta-analysis. 23821300

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a meta-analysis. 24142527

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE The present results indicate that targeting the TNF-α/TNFR1 pathway may be an effective preventive or therapeutic strategy for gastric cancer. 23975421

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Quantitative assessment of the influence of tumor necrosis factor alpha polymorphism with gastritis and gastric cancer risk. 24072494

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Tumor necrosis factor-α 238 G/A polymorphism and gastric cancer risk: a meta-analysis. 23900678

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE The binding complex of nucleolin and Tipα induces expression of TNF-α and chemokine genes and activates NF-κB in gastric cancer cells of humans and mice. 24469254

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-α-inducing protein of Helicobacter pylori. 24249671

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE To investigate the prognostic significance of tumor necrosis factor receptor (TNFR),-associated factor 6 (TRAF6),-and ubiquitin in gastric cancer patients. 23013936

2013

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Transcriptional and post-translational regulation of Bim is essential for TGF-β and TNF-α-induced apoptosis of gastric cancer cell. 23500081

2013

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Functional promoter -308G>A variant in tumor necrosis factor α gene is associated with risk and progression of gastric cancer in a Chinese population. 23326309

2013

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Moreover, the expression of miR-7 in human gastric cancer was inversely correlated with the levels of interleukin-1β and tumor necrosis factor-α, suggesting that miR-7 downregulation is related to the severity of inflammatory responses. 22139078

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori. 22459353

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Depletion of OLFM4 gene inhibits cell growth and increases sensitization to hydrogen peroxide and tumor necrosis factor-alpha induced-apoptosis in gastric cancer cells. 22471589

2012