Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression BEFREE The positive expression of HER4 was correlated with the prognosis of SNMMM patients (P<0.05). 29309357

2018

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Here we want to share our experience regarding major problems associated with FFPE DNA used for PCR-based sequencing as illustrated by the mutational analysis of ERBB4 in melanoma. 28314930

2017

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE At the same time, high throughput sequencing studies of melanoma unraveled a series of new treatment candidates for future treatment approaches such as ERBB4, GRIN2A, GRM3, and RAC1. 25654738

2015

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Our results further emphasize the role of HER4 as an important oncogene in malignant melanoma and point to HER4 as a possible drug target in this disease. 24366194

2014

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE This sequencing technique has successfully been applied within a clinical trial selecting patients with ERBB4-mutant melanoma for lapatinib treatment. 24258993

2014

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Malignant transformation of melanomas is accompanied by loss of KIT and acquisition of EPO-R and ErbB4, both of which are co-expressed with NGF-R and PD-1 in distinct subfractions of melanoma cells. 24489649

2014

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Mutations in melanoma cell lines correlated with their sensitivity to corresponding small molecule inhibitors, confirming, for example, lapatinib sensitivity in ERBB4 mutant lines and identifying a novel activating mutation of BRAF. 24628946

2014

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, targeting the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy. 23237222

2013

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Ligand-mediated activation of ErbB3 and ErbB4 is implicated in the pathogenesis of several human malignancies including cancer of the ovary and melanoma. 22856597

2012

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Gaining further understanding into the oncogenic mechanism of Erbb4 may not only help in the development of targeted therapy in melanoma patients but might accelerate the acceptance of a novel taxonomy of cancer which is based on the genomic perturbations in cancer genes and cancer gene families and their response to targeted agents. 20404484

2010

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE We found ERBB4 mutations in 19% of individuals with melanoma and found mutations in two other kinases (FLT1 and PTK2B) in 10% of individuals with melanomas. 19718025

2009

Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE A therapeutic opportunity in melanoma: ErbB4 makes a mark on skin. 19800573

2009