Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE We aimed to analyze GNAQ and GNA11 mutations in uveal melanomas using formalin-fixed, paraffin-embedded material and correlate the results with clinicopathological parameters. 29209985

2019

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Although the role of guanine nucleotide-binding protein subunit α (GNA) 11 (GNA11) in melanoma has been described, the involvement of GNA14 in endometrial carcinoma remains to be determined. 30054423

2018

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression BEFREE Integrative transcriptome analysis of human and murine melanomas identified RasGRP3 to be specifically expressed in GNAQ/GNA11-driven melanomas. 29490280

2018

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Blue nevi are known to be genetically related to uveal melanomas (eg, both harboring GNAQ and GNA11 mutations). 28409567

2017

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Other pigmented neoplasms, such as uveal melanomas and melanocytomas (MCs), are associated with genetic defects in other genes including GNA11. 28012237

2017

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Recent genomic studies have shown that mutations within components of G protein-coupled receptor (GPCR) signaling are early events associated with approximately 98% of uveal melanomas.<b>Implications:</b> This review discusses the alterations in GPCR signaling components (GNAQ and GNA11), dysregulated GPCR signaling cascades, and viable targeted therapies with the intent to provide insight into new therapeutic strategies in uveal melanoma.<i></i>. 28223438

2017

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Thus, CRAF is a bona fide alternative oncogene for BRAF/NRAS/GNAQ/GNA11 wild type melanomas. 27273450

2016

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Gene mutations involving GNAQ and GNA11 were each detected in two of eight melanomas ex blue nevi. 26743478

2016

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE To our knowledge, this is the first case report to demonstrate cutaneous origin melanoma harboring a GNA11 Q209L mutation. 26825879

2016

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Twenty primary LMNs ranging from benign and intermediate-grade melanocytomas to melanomas were tested by direct sequencing for hotspot mutations in the genes GNA11, GNAQ, BRAF, NRAS and HRAS. 25315378

2015

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE GNAQ and GNA11, two oncogenes in BRAF and NRAS wild-type uveal melanomas, were not mutated in our cohort. 25769001

2015

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE These G-alpha protein mutations occur in the genes GNAQ and GNA11 and are seen at a high frequency in uveal melanomas, those melanomas that begin in the eye. 25030020

2014

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE The tumour showed mutations in GNA11 and EIF1AX that are typical for uveal melanoma and absent from cutaneous melanoma. 24423917

2014

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE To examine whether GNAQ and GNA11 somatic mutations previously identified in uveal melanomas of Caucasians are associated with uveal melanomas in Chinese patients. 25280020

2014

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE However, somatic mutations in either GNAQ or GNA11 are unique to UM tumors and could be used as potential markers to differentiate UM from metastatic CM and act as direct therapeutic targets. 24697775

2014

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. 24458518

2014

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Deep sequencing studies show that 4.2% of tumours carry activating mutations in GNAS (encoding Gαs), and that oncogenic activating mutations in genes encoding Gαq family members (GNAQ or GNA11) are present in ~66% and ~6% of melanomas arising in the eye and skin, respectively. 23640210

2013

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Only 1 out of 92 (1.1%) melanomas showed a mutation in GNA11 exon 4 codon 183, whereas 39 out of 92 (42.4%) harboured a mutation in exon 5 of GNA11 codon 209. 23778528

2013

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Primary CNS melanocytic neoplasms, including uveal melanomas have frequent mutations in GNAQ and GNA11, but are rare in cutaneous and mucosal melanomas. 24274719

2013

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Recently, mutually exclusive oncogenic mutations in melanomas involving NRAS (15-20%), BRAF (50%), CKIT (2%), and GNAQ/GNA11 (50% of uveal melanomas) have been identified. 21482206

2011

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Mutations affecting R183 in either GNAQ or GNA11 were less prevalent (2% of blue nevi and 6% of uveal melanomas) than the Q209 mutations. 21083380

2010