Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 PosttranslationalModification BEFREE Somatic oncogenic mutation of BRAF coupled with inactivation of PTEN constitute a frequent combination of genomic alterations driving the development of human melanoma. 31065107

2020

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE PTEN immunohistochemical loss, a common event in endometrioid-type endometrial carcinoma and associated with local immune suppression in melanoma, was not associated with PD-L1 expression or lymphocyte/macrophage infiltration of the tumor. 30291344

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells. 30863489

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 AlteredExpression BEFREE The dCas9-VPR system increased PTEN expression in melanoma and TNBC cell lines, without transcriptional regulation at predicted off-target sgRNA binding sites. 30654190

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE PTEN genomic alterations (deletion, mutation), promoter methylation, and protein destabilization did not fully explain PTEN loss in melanoma, whereas PTEN levels increased with treatment of melanoma cells with the histone deacetylase inhibitor LBH589. 30148988

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE C-Jun drives melanoma progression in PTEN wild type melanoma cells. 31378787

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE We also evaluated the antitumor activity of an anti-OX40 antibody plus PI3Kβ inhibition in a transgenic murine melanoma model (<i>Braf</i> mutant, PTEN null), which spontaneously develops immunotherapy-resistant melanomas. 31371342

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE The frequencies of somatic mutations in BRAF (96%) and PTEN (36%) in the AYA WGS cohort were double the rates observed in adult melanomas (Q < 6.0 × 10<sup>-6</sup> and 0.028, respectively). 30178487

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE MiR-637 suppresses melanoma progression through directly targeting P-REX2a and inhibiting PTEN/AKT signaling pathway. 30213289

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE Additionally, p62 forms a feedback loop with PTEN in melanoma cells, suggesting p62 functions as an oncogene in UVA-associated melanoma development and progression. 28715145

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE The metformin/sitagliptin combination was effective in a BRAFV600E/PTEN tamoxifen-inducible murine melanoma model. 29899823

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE Moreover, we identified AXL as a key upstream effector of AKT pathway-associated resistance to BRAFi in melanoma with wildtype PTEN, but not in melanoma with impaired PTEN. 29551771

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE Functional and genomic analyses of patient-derived melanomas revealed that PTEN loss is associated with NHEJ deficiency. 29739874

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE Suppression of MAPK signaling in BRAF-activated PTEN-deficient melanoma by blocking β-catenin signaling in cancer-associated fibroblasts. 29045061

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE We observe selection for low-abundance PTEN variants in cancer, and show that p.Pro38Ser, which accounts for ~10% of PTEN missense variants in melanoma, functions via a dominant-negative mechanism. 29785012

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 AlteredExpression BEFREE Moreover, miR-331 suppressed the activation of the PTEN/AKT signalling pathway in melanoma by inhibiting AEG-1. 29510779

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE <i>PHIP</i> copy number was enriched in metastatic melanomas harboring mutant <i>NRAS</i> or expressing PTEN protein (cohort No.2). 29776954

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE Co-treatment of phenformin enhances the effect of anti-PD-1 antibody therapy on inhibiting tumor growth in the BRAF V600E/PTEN-null melanoma mouse model. 28433543

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE Thus, these data not only provide mechanistic insight into Abl/Arg regulation during melanoma development, but also pave the way for the development of new strategies for treating patients with melanomas harboring mutant BRAF/PTEN, which often are refractory to current therapies. 28368422

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE Treatment with ST-162 produced regression of mutant KRAS- or BRAF-addicted xenograft models of colorectal cancer and melanoma and stasis of BRAF/PTEN-mutant melanomas. 28775144

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE Here, we show that concurrent loss of PTEN and activation of the Notch pathway is associated with poor response to the ERK inhibitor SCH772984, and that co-inhibition of Notch and ERK decreased viability in BRAF-V600E melanomas. 27655717

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 AlteredExpression BEFREE Analysis of a melanoma tissue microarray showed loss of PTEN expression to predict for a lower overall survival, with a trend for even lower survival being seen when loss of fibronectin was included in the analysis. 26073081

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE Taken together, our findings provide a strong rationale for testing combinations of panPI3K, PI3Kβ + IGF1R, and MAPK pathway inhibitors in PTEN(LOF)/BRAF(MUT) melanoma patients to achieve maximal response. 26577700

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE We demonstrate that SAR260301 blocks PI3K pathway signaling preferentially in PTEN-deficient human tumor models, and has synergistic antitumor activity when combined with vemurafenib (BRAF inhibitor) or selumetinib (MEK inhibitor) in PTEN-deficient/BRAF-mutated human melanoma tumor models. 27196754

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0025202
Disease: melanoma
melanoma
0.800 AlteredExpression BEFREE Peng and colleagues describe the effects of PTEN inactivation on antitumor immunity and response to immune checkpoint blockade in melanoma. 26851183

2016