Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE The MYC oncogene, known to drive myeloma progression, was downregulated in both in vitro and in vivo models when treated with [Au(d2pype)<sub>2</sub>]Cl. 31514052

2020

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 AlteredExpression BEFREE Microhomology-mediated end joining drives complex rearrangements and over expression of MYC and PVT1 in multiple myeloma. 31221783

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE As proof of concept, we identified a low micromolar potency molecule (compound 30666) that inhibited immunoglobulin production by MM cells and blocked expression of an array of IgH translocation-induced oncogenes (CCND1, FGFR3/MMSET, and MYC) in MM and NHL cell lines. 30481117

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 AlteredExpression BEFREE Ex vivo pharmacodynamic analyses demonstrated that the combination of JQ1 and ricolinostat led to significantly lower MM cell proliferation and increased apoptosis and diminished expression of c-MYC and BCL-2. 31015208

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Vk*MYC mice under glyphosate exposure developed progressive hematological abnormalities and plasma cell neoplasms such as splenomegaly, anemia, and high serum IgG. 31277689

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE We developed preclinical models of bone marrow transplantation (BMT) for MM using Vk*MYC myeloma-bearing recipient mice and donor mice that were myeloma naive or myeloma experienced to simulate autologous transplantation. 30300141

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Immunocompetent models, in particular the 5T series and Vk<sup>⁎</sup>MYC models, are increasingly being utilized in preclinical studies and are adding to our knowledge of not only the adaptive immune system but also how the innate system might be enhanced in anti-MM activity. 31093282

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Importantly, 78% of IgL-MYC translocations co-occur with hyperdiploid disease, a marker of standard risk, suggesting that IgL-MYC-translocated myeloma is being misclassified. 31015454

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 AlteredExpression BEFREE Furthermore, promoter derepression of TAZ expression sensitizes MM cell lines through a reciprocal reduction in MYC expression using additional therapeutics such as bortezomib, trichostatin A, and panobinostat. 31743393

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Using the syngeneic Vk*MYC BTZ-resistant immunocompetent transplantable MM murine model, we also demonstrate that mice harboring BTZ-insensitive MM tumors respond to the RV/BTZ combination treatment in terms of decreased tumor burden and improved overall survival (<i>P</i> < .00001). 30850386

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Our experimental results further demonstrate that Co-fuse can identify known driver fusion genes (e.g., IGH-MYC, IGH-WHSC1) in MM, when compared to AML samples, indicating the potential of Co-fuse to aid the discovery of yet unknown driver fusion genes through cohort comparisons. 29882166

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE In this review, we describe the mechanism of MYC activation in MM, the role of MYC in cancer progression, and the therapeutic options to targeting MYC. 29467490

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Mice deficient for IL-18 were remarkably protected from Vk<sup>∗</sup>MYC MM progression in a CD8<sup>+</sup> T cell-dependent manner. 29551594

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE The severe combined immune deficiency (SCID) mouse xenograft model revealed that compound 7594-0035 partially decreased the primary tumor growth of Roswell Park Memorial Institute (RPMI)-8226 cells <i>in vivo</i> The novel small molecular compound 7594-0035 described in the present study that targets c-Myc protein is likely to be a promising therapeutic agent for relapsed/refractory MM. 30068698

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 AlteredExpression BEFREE Our results indicate myc protein overexpression to be associated with advanced multiple myeloma and poor prognosis. 29999206

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Since MYC is frequently hyperactivated in MM and inhibition of MYC leads to MM cell death. 29472861

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 AlteredExpression BEFREE Finally, measuring the levels of 2-HG in the BM supernatant and peripheral blood plasma from patients with precursor PC malignancies such as smoldering MM (SMM) demonstrates that relatively elevated levels of 2-HG are associated with higher levels of c-MYC expression in the BM clonal PCs and with a subsequent shorter time to progression (TTP) to MM. 29321378

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Thus, in Vk*MYC mice, commensal bacteria appear to unleash a paracrine signaling network between adaptive and innate immunity that accelerates progression to MM, and can be targeted by already available therapies. 30510245

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE As such, the Ig and MYC loci are key players in the myeloma genome and including these in any genomic studies is key to understanding the relationship with other abnormalities. 29797253

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Our results indicate that PCM with MYC related abnormalities in general have advanced tumors and adverse outcomes even with low proliferation. 30553464

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 AlteredExpression BEFREE Expression profiling of MM cells revealed reversion of the oncogenic MYC-driven transcriptional program by CMLD010509, the most promising rocaglate. 28490664

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Glutaminase inhibition in multiple myeloma induces apoptosis <i>via</i> MYC degradation. 29156762

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE The MUC1-C oncoprotein is aberrantly expressed by MM cells, activates MYC and is also necessary for MM cell survival. 29050200

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE Collectively, these studies provide a rationale for the clinical translation of CX-5461 as a novel therapeutic approach to target MYC in myeloma. 28369725

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.400 Biomarker BEFREE These findings reveal a novel mechanism of therapeutic targeting of MYC through the LIN28B/let-7 axis in MM that may impact other MYC-dependent cancers as well. 27773931

2017